Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom

2006 ◽  
Vol 119 (3) ◽  
pp. 1834-1848 ◽  
Author(s):  
Vera A. Khokhlova ◽  
Michael R. Bailey ◽  
Justin A. Reed ◽  
Bryan W. Cunitz ◽  
Peter J. Kaczkowski ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Lesion Formation ◽  
Gel Phantom

Nonlinear Derating of High-Intensity Therapeutic Ultrasound Beams Using Gaussian Modal Sums

2013 ◽  
Author(s):  
Seyed Ahmad Reza Dibaji ◽  
Matthew R. Myers ◽  
Joshua E. Soneson ◽  
Rupak K. Banerjee
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Tissue Temperature ◽  
Medical Procedure ◽  
Pressure Amplitude ◽  
Pressure Trace ◽  
The Difference ◽  
Semi Empirical

High intensity focused ultrasound (HIFU) is a noninvasive medical procedure during which a large amount of energy is deposited in a short duration which causes sudden localized rise in tissue temperature, and ultimately, cell necrosis. In assessing the influence of HIFU on biological tissue, semi-empirical mathematical models can be useful for predicting thermal effects. These models require values of the pressure amplitude in the tissue of interest, which can be difficult to obtain experimentally. One common method for estimating the pressure amplitude in tissue is to operate the HIFU transducer in water, measure the pressure amplitude, then multiply by a scaling factor that accounts for the difference in attenuation between water and tissue. This procedure can be accurate when the ultrasound amplitude is low, and the pressure trace in tissue is proportional to that in water. Because of this proportionality, the procedure for reducing the amplitude from water to tissue is called linear derating. At higher intensities, however, harmonics of the fundamental frequency are generated due to nonlinear propagation effects. Higher harmonics are attenuated differently in water and tissue (Hamilton and Blackstock [1]), and the pressure waves in water and tissue are no longer proportional to one another. Techniques for nonlinearly transforming pressure amplitudes measured in water to values appropriate for tissue are therefore desirable when bioeffects of higher intensity procedures are being studied. These techniques are labeled “nonlinear derating”.

Acousto‐optic monitoring of high‐intensity focused ultrasound lesion formation in optically diffuse tissue.

2010 ◽  
Vol 127 (3) ◽  
pp. 2039-2039
Author(s):  
Puxiang Lai ◽  
James R. McLaughlan ◽  
Andrew B. Draudt ◽  
Todd W. Murray ◽  
Robin O. Cleveland ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Lesion Formation

Effects of soft tissue inhomogeneities on nonlinear propagation and shock formation in high intensity focused ultrasound beams

2017 ◽  
Vol 141 (5) ◽  
pp. 3548-3548 ◽  
Author(s):  
Petr V. Yuldashev ◽  
Anastasia S. Bobina ◽  
Tatiana D. Khokhlova ◽  
Adam D. Maxwell ◽  
Wayne Kreider ◽  
...  
Keyword(s):  
Soft Tissue ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Shock Formation

Novel bilayer aberration-inducing gel phantom for high-intensity focused ultrasound applications

2019 ◽  
Vol 146 (4) ◽  
pp. 3072-3072
Author(s):  
Alex T. Peek ◽  
Tatiana D. Khokhlova ◽  
Pavel B. Rosnitskiy ◽  
Petr V. Yuldashev ◽  
Christopher R. Bawiec ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Applications ◽  
Gel Phantom
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