Effects of soft tissue inhomogeneities on nonlinear propagation and shock formation in high intensity focused ultrasound beams

2017 ◽  
Vol 141 (5) ◽  
pp. 3548-3548 ◽  
Author(s):  
Petr V. Yuldashev ◽  
Anastasia S. Bobina ◽  
Tatiana D. Khokhlova ◽  
Adam D. Maxwell ◽  
Wayne Kreider ◽  
...  
Keyword(s):  
Soft Tissue ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Shock Formation

Nonlinear Derating of High-Intensity Therapeutic Ultrasound Beams Using Gaussian Modal Sums

2013 ◽  
Author(s):  
Seyed Ahmad Reza Dibaji ◽  
Matthew R. Myers ◽  
Joshua E. Soneson ◽  
Rupak K. Banerjee
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Tissue Temperature ◽  
Medical Procedure ◽  
Pressure Amplitude ◽  
Pressure Trace ◽  
The Difference ◽  
Semi Empirical

High intensity focused ultrasound (HIFU) is a noninvasive medical procedure during which a large amount of energy is deposited in a short duration which causes sudden localized rise in tissue temperature, and ultimately, cell necrosis. In assessing the influence of HIFU on biological tissue, semi-empirical mathematical models can be useful for predicting thermal effects. These models require values of the pressure amplitude in the tissue of interest, which can be difficult to obtain experimentally. One common method for estimating the pressure amplitude in tissue is to operate the HIFU transducer in water, measure the pressure amplitude, then multiply by a scaling factor that accounts for the difference in attenuation between water and tissue. This procedure can be accurate when the ultrasound amplitude is low, and the pressure trace in tissue is proportional to that in water. Because of this proportionality, the procedure for reducing the amplitude from water to tissue is called linear derating. At higher intensities, however, harmonics of the fundamental frequency are generated due to nonlinear propagation effects. Higher harmonics are attenuated differently in water and tissue (Hamilton and Blackstock [1]), and the pressure waves in water and tissue are no longer proportional to one another. Techniques for nonlinearly transforming pressure amplitudes measured in water to values appropriate for tissue are therefore desirable when bioeffects of higher intensity procedures are being studied. These techniques are labeled “nonlinear derating”.

Mechanical High-Intensity Focused Ultrasound Destruction of Soft Tissue: Working Mechanisms and Physiologic Effects

2015 ◽  
Vol 41 (6) ◽  
pp. 1500-1517 ◽  
Author(s):  
Martijn Hoogenboom ◽  
Dylan Eikelenboom ◽  
Martijn H. den Brok ◽  
Arend Heerschap ◽  
Jurgen J. Fütterer ◽  
...  
Keyword(s):  
Soft Tissue ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Working Mechanisms

Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom

2006 ◽  
Vol 119 (3) ◽  
pp. 1834-1848 ◽  
Author(s):  
Vera A. Khokhlova ◽  
Michael R. Bailey ◽  
Justin A. Reed ◽  
Bryan W. Cunitz ◽  
Peter J. Kaczkowski ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Nonlinear Propagation ◽  
Lesion Formation ◽  
Gel Phantom

scholarly journals Feasibility of targeting canine soft tissue sarcoma with MR-guided high-intensity focused ultrasound

2018 ◽  
Vol 35 (1) ◽  
pp. 205-215 ◽  
Author(s):  
Marion C. Seward ◽  
Gregory B. Daniel ◽  
Jeffrey D. Ruth ◽  
Nikolaos Dervisis ◽  
Ari Partanen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound

NUMERICAL SIMULATION OF TEMPERATURE ELEVATION IN SOFT TISSUE BY HIGH INTENSITY FOCUSED ULTRASOUND

2008 ◽  
Vol 22 (11) ◽  
pp. 803-807 ◽  
Author(s):  
KANG IL LEE ◽  
IMBO SIM ◽  
GWAN SUK KANG ◽  
MIN JOO CHOI
Keyword(s):  
Numerical Simulation ◽  
Soft Tissue ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Focal Length ◽  
The Body ◽  
High Intensity Focused Ultrasound ◽  
Bioheat Transfer ◽  
Center Frequency ◽  
Temperature Elevation

In focused ultrasound surgery, high intensity focused ultrasound (HIFU) can be used to destroy pathological tissue deep inside the body without any damage to the surrounding normal tissue. This noninvasive technique has been used to treat malignant tumors of the liver, prostate, kidney, and benign breast tumors via a percutaneous or transrectal approach without the need for general anaesthesia. In the present study, a finite element method was used for the simulation of temperature elevation in soft tissue by HIFU. First, the HIFU field was modeled using the Westervelt equation for the propagation of finite-amplitude sound in a thermoviscous fluid in order to account for the effects of diffraction, absorption, and nonlinearity. Second, the Pennes bioheat transfer equation was used to predict the temperature elevation in soft tissue by HIFU. In order to verify the numerical simulation, the simulated temperature elevation at the focus in a tissue-mimicking phantom was compared with the measurements, using a concave focused transducer with a focal length of 62.6 mm, a radius of 35.0 mm, and a center frequency of 1.1 MHz.

High intensity focused ultrasound treatment in late stage bone and soft tissue malignances

2012 ◽  
Author(s):  
Li Min ◽  
Wang Baosheng ◽  
Sun Baoyong ◽  
Wang Hui ◽  
Li Xianghong ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Late Stage ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Treatment
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