Intraspeaker variability in fundamental frequency stability: An age‐related phenomenon?

1988 ◽  
Vol 83 (2) ◽  
pp. 741-745 ◽  
Author(s):  
Sue Ellen Linville
Keyword(s):  
Fundamental Frequency ◽  
Frequency Stability ◽  
Related Phenomenon ◽  
Age Related

Loss of the Y Chromosome: An Age-Related or Clonal Phenomenon in Acute Myelogenous Leukemia/Myelodysplastic Syndrome?

2008 ◽  
Vol 132 (8) ◽  
pp. 1329-1332
Author(s):  
Anna K. Wong ◽  
Belle Fang ◽  
Ling Zhang ◽  
Xiuqing Guo ◽  
Stephen Lee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndrome ◽  
Y Chromosome ◽  
Acute Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Related Phenomenon ◽  
Patients Âgés ◽  
Age Related ◽  
Acute Myelogenous ◽  
Bone Marrow Analysis

Abstract Context.—The clinical association between loss of the Y chromosome and acute myelogenous leukemia and myelodysplastic syndrome (AML/MDS) has been debated because both phenomena are related to aging. A prior publication suggests that loss of the Y chromosome in more than 75% of cells may indicate a clonal phenomenon that could be a marker for hematologic disease. Objective.—To evaluate the relationship between loss of the Y chromosome and AML/MDS. Design.—A retrospective review of cytogenetic reports of 2896 male patients ascertained from 1996 to 2007 was performed. Results were stratified based on the percentage of cells missing the Y chromosome and were correlated with patients' ages and bone marrow biopsy reports through logistic regression analysis with adjustment for age. Results.—Loss of the Y chromosome was found in 142 patients. Of these, 16 patients demonstrated myeloid disease, with 2 cases of AML and 14 cases of MDS. An increased incidence (P < .05) of AML/MDS was seen only in the group composed of 8 patients with complete loss of the Y chromosome in all karyotyped cells (1 case of AML and 7 cases of MDS). Conclusion.—Loss of the Y chromosome appears to be primarily an age-related phenomenon. However, in individuals in which all cells on cytogenetic analysis showed loss of the Y chromosome, there was a statistically significant increase in AML/MDS, suggesting that the absence of any normal-dividing cells in a bone marrow analysis may be indicative of AML/MDS.

Cytoplasmic Granules in Buccal Cells: An Age-related Phenomenon ? (Age Difference in Cell Graunlation)

1972 ◽  
Vol 27 (1) ◽  
pp. 18-21 ◽  
Author(s):  
R. W. Hillman ◽  
H. S. Smith ◽  
J. S. Levine
Keyword(s):  
Age Difference ◽  
Related Phenomenon ◽  
Buccal Cells ◽  
Cytoplasmic Granules ◽  
Age Related

scholarly journals Mesenteric Panniculitis (MP): A Frequent Coincidental CT Finding of Debatable Clinical Significance

2018 ◽  
Vol 190 (11) ◽  
pp. 1044-1052
Author(s):  
Özlem Gögebakan ◽  
Martin Osterhoff ◽  
Thomas Albrecht
Keyword(s):  
Malignant Lymphoma ◽  
Case Reports ◽  
Related Phenomenon ◽  
Sclerosing Mesenteritis ◽  
Mesenteric Panniculitis ◽  
Case Control Studies ◽  
Mesenteric Lymph Nodes ◽  
Scientific Debate ◽  
Age Related ◽  
Ct Finding

Background Mesenteric panniculitis (MP) is histologically characterized by chronic nonspecific inflammation of the adipose tissue of the intestinal mesentery with unclear etiology. MP occurs predominantly in men, mostly in mid to late adulthood. MP is typically found as an incidental diagnosis on abdominal CT. Methods A comprehensive review of the literature including case reports and cohort studies was performed. Therefore, a global search in PubMed was carried out. Search terms were (and/or) “mesenteric panniculitis”, “panniculitis mesenterialis”, “mesenteric lymph nodes”, “CT”, “imaging”, “sclerosing mesenteritis”, “case report”, “therapy”. Results and Conclusion MP is a relatively common CT finding. The true prevalence seems to be higher than the reported 0.6 % to 2.4 % due to underreporting. The most important differential diagnosis is malignant lymphoma, which may be difficult to distinguish from MP. The majority of patients with MP are clinically asymptomatic and do not require therapy. In rare symptomatic cases, non-specific symptoms like abdominal pain, fever, nausea or vomiting occur. For therapy, glucocorticoids and tamoxifen have been suggested. Several studies suggested that MP is associated with other diseases and might be a paraneoplastic phenomenon, but four recently published case-control studies suggest that MP is an independent non-specific benign age-related phenomenon. However, two further studies show a possible association of MP with malignant lymphoma. The clinical relevance of MP remains the subject of scientific debate. Key Points:  Citation Format

Cardiac sympathetic denervation in wild-type transthyretin amyloidosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Aimo ◽  
A Gimelli ◽  
G Vergaro ◽  
D Genovesi ◽  
A Kusch ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Reference Value ◽  
Sympathetic Denervation ◽  
Related Phenomenon ◽  
Amyloid Burden ◽  
Wild Type ◽  
Transthyretin Amyloidosis ◽  
Age Related ◽  
99Mtc Tetrofosmin ◽  
Cardiac Sympathetic Denervation

Abstract Background Tissue accumulation of misfolded transthyretin (TTR) may occur because of TTR gene mutations (variant amyloid TTR amyloidosis, ATTRv), or as an age-related phenomenon (wild-type ATTR, ATTRwt). Cardiac sympathetic denervation has been reported in ATTRv, but has never been investigated in ATTRwt. Methods Fifteen consecutive patients with ATTRwt cardiomyopathy (81% men, median age 82 years, no one with prior myocardial infarction) underwent Cadmium Zinc Telluride tomographic imaging for amyloid burden (99mTc-hydroxymethylene diphosphonate - 99mTc-HMDP), innervation (123I-metaiodobenzylguanidine – 123I-MIBG), and perfusion (99mTc-tetrofosmin). Results Median summed 99mTc-HMDP score was 60 (58–62), denoting a severe and diffuse amyloid burden. Planar 123I-MIBG examination showed decreased early and late H/M ratios (late H/M ratio: 1.5 [1.3–1.6], range 1.2–1.9, reference value ≥2.0). Summed 123I-MIBG score was 12 (6–22), with the most prominent denervation in the infero-septal, inferior, and infero-lateral regions; summed rest score was 7 (5–11), with lowest degrees of myocardial perfusion in the inferior and infero-septal regions. The correlation between amyloid burden (as relative 99mTc-HMDP uptake) and innervation (as relative 123I-MIBG uptake) did not achieve statistical significance at both segmental (p=0.252) and regional level (p=0.251). Nevertheless, denervation tended to worsen in parallel with the amyloid burden, and 123I-MIBG scores increased with 99mTc-HMDP scores. Segments and regions with more prominent hypoperfusion were those showing the more intense denervation (r=0.500 and 0.591, respectively; both p<0.001). Conclusions Patients with ATTRwt cardiomyopathy display cardiac sympathetic denervation, particularly in the inferior and septal myocardial wall. Myocardial hypoperfusion has a similar regional pattern, while the amyloid burden is more extensive. Funding Acknowledgement Type of funding source: None

Is postmenopausal bone loss an age-related phenomenon?

1986 ◽  
Vol 39 (3) ◽  
pp. 123-127 ◽  
Author(s):  
Karsten Thomsen ◽  
Anders Gotfredsen ◽  
Claus Christiansen
Keyword(s):  
Bone Loss ◽  
Postmenopausal Bone Loss ◽  
Related Phenomenon ◽  
Age Related

Sexual dimorphism in arterial hypertension: an age-related phenomenon

2000 ◽  
Vol 29 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Roberto Antonicelli ◽  
Rosaria Gesuita ◽  
Enrico Paciaroni
Keyword(s):  
Sexual Dimorphism ◽  
Arterial Hypertension ◽  
Related Phenomenon ◽  
Age Related

scholarly journals Prevalence of Age-Associated Testosterone Deficiency Syndrome in Indian Population

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Ghanendra Kumar Yadav ◽  
Mrinal Pahwa ◽  
Mahendra Singh ◽  
Vipin Tyagi ◽  
Sudhir Chadha
Keyword(s):  
Serum Testosterone ◽  
Free Testosterone ◽  
Deficiency Syndrome ◽  
Related Phenomenon ◽  
Aging Male ◽  
Testosterone Deficiency ◽  
Male Population ◽  
Age Related ◽  
Study Population ◽  
Testosterone Deficiency Syndrome

Testosterone deficiency syndrome (TDS) is a gradual age-related phenomenon that occurs in a large proportion of the aging male population. This current prospective study was done with the objective to estimate the prevalence of age-associated TDS in India and its clinical profile. A total of 800 male patients aged ≥40 year were approached to participate in the study. A brief history and focused examination was done. Based on our exclusion criteria, 55 patients were excluded. Androgen deficiency in aging male (ADAM) questionnaire was administered to all remaining 745 patients. Out of these 745 patients, ADAM-positive (symptomatic TDS) patients were found to be 359 and enrolled in the study. In all ADAM-positive patients, serum testosterone levels were measured. Prevalence of symptomatic TDS in study population was found to be 48.18%. Mean total and free testosterone level of symptomatic TDS population were 3.287 ± 1.494 ng/ml (1.12–9.61) and 7.476 ± 2.902 pg/ml (2.18–21.76), respectively. Prevalence of biochemically confirmed TDS among symptomatic TDS population was 60.17%. Prevalence of TDS increases progressively with each decade of life (p=0.034). Prevalence was higher in patients with diabetes, hypertension, coronary artery disease, obesity, and metabolic syndrome. TDS is a real phenomenon with a prevalence of 28.99% in our study population.

Late-onset mitochondrial neuromyopathy: an age-related phenomenon?

1996 ◽  
Vol 22 ◽  
pp. 577-583
Author(s):  
A. Toscano ◽  
M. Santoro ◽  
G. Vita ◽  
P. Girlanda ◽  
S. Sinicropi ◽  
...  
Keyword(s):  
Late Onset ◽  
Related Phenomenon ◽  
Age Related
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