Nonlinear dynamics of the organ of Corti, modeling both outer hair cell somatic motility and hair bundle motility

2015 ◽  
Vol 137 (4) ◽  
pp. 2410-2410 ◽  
Author(s):  
Amir Nankali ◽  
Aritra Sasmal ◽  
Karl Grosh
Keyword(s):  
Nonlinear Dynamics ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Organ Of Corti ◽  
Hair Bundle

scholarly journals Outer Hair Cell Somatic Electromotility In Vivo and Power Transfer to the Organ of Corti

2012 ◽  
Vol 102 (3) ◽  
pp. 388-398 ◽  
Author(s):  
Sripriya Ramamoorthy ◽  
Alfred L. Nuttall
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Organ Of Corti ◽  
Power Transfer

scholarly journals Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e23729 ◽  
Author(s):  
Li-Dong Zhao ◽  
Wei-Wei Guo ◽  
Chang Lin ◽  
Li-Xian Li ◽  
Jian-He Sun ◽  
...  
Keyword(s):  
Hair Cell ◽  
Organ Of Corti ◽  
Hair Bundle ◽  
Neonatal Rats ◽  
Cell Production

scholarly journals A gap-junction mutation in the mouse cochlea reveals cochlear amplification is driven by outer hair cell extracellular receptor potentials

2021 ◽  
Author(s):  
Snezana Levic ◽  
Victoria A Lukashkina ◽  
Patricio Simoes ◽  
Andrei N Lukashkin ◽  
Ian J Russell
Keyword(s):  
Hair Cell ◽  
Gap Junction ◽  
High Frequency ◽  
Outer Hair Cell ◽  
Stria Vascularis ◽  
Organ Of Corti ◽  
Receptor Potential ◽  
Wild Type ◽  
Hearing Sensitivity ◽  
Cochlear Amplification

Cochlear amplification, whereby cochlear responses to low-to-moderate sound levels are 31 amplified and compressed to loud sounds, is attributed to outer hair cell (OHC) electromotility 32 driven by voltage changes across the OHC basolateral membranes due to sound-induced 33 receptor-current modulation. Cochlear operation at high acoustic frequencies is enigmatic 34 because the OHC intracellular receptor potential (RP) is severely attenuated at these 35 frequencies. Clues to understanding the voltage control of OHC electromotility at different 36 frequencies was provided by measurements from CD-1 mice with an A88V mutation of the 37 gap-junction (GJ) protein connexin 30 (Cx30), which with Cx26, form heterogeneous GJs 38 between supporting cells in the organ of Corti (OoC) and stria vascularis. The A88V mutation 39 results in a smaller GJ conductance which may explain why the resistance across the OoC in 40 CD-1Cx30A88V/A88V mutants is higher compared with wild-type mice. The endocochlear 41 potential, which drives the OHC receptor current and, consequently, the OHC RPs, is smaller 42 in CD-1Cx30A88V/A88V mutants. Even so, their high-frequency hearing sensitivity equals that of 43 wild-type mice. Preservation of high-frequency hearing correlates with similar amplitude of 44 extracellular receptor potentials (ERPs), measured immediately adjacent to the OHCs. ERPs 45 are generated through OHC receptor current flow across the OoC electrical resistance, which 46 is larger in CD-1Cx30A88V/A88V than in wild-type mice. Thus, smaller OHC receptor currents 47 flowing across a larger OoC resistance in CD-1Cx30A88V/A88V mice may explain why their ERP 48 magnitudes are similar to wild-type mice. It is proposed that the ERPs, which are not subject 49 to low-pass electrical filtering, drive high-frequency cochlear amplification.

Morphology of Synapses at the Base of Hair Cells in the Organ of Corti of the Chimpanzee

1990 ◽  
Vol 99 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Joseph B. Nadol ◽  
Barbara J. Burgess
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Single Neuron ◽  
Outer Hair Cell ◽  
Mammalian Species ◽  
Organ Of Corti ◽  
Outer Hair Cells ◽  
Nerve Terminals ◽  
Section Electron ◽  
Serial Section Electron Microscopy

The synaptic morphology of inner and outer hair cells of the organ of Corti of the chimpanzee was evaluated by serial section electron microscopy. The morphology of nerve terminals and synapses at both sites was very similar to that of human and other mammalian species. Two types of nerve terminals, nonvesiculated and vesiculated, with distinct synaptic morphology were found. In addition, between some nonvesiculated endings and outer hair cells, a reciprocal synaptic relationship was seen. In such terminals there was morphologic evidence for transmission from hair cell to neuron and from neuron to hair cell between a single neuron and an outer hair cell.

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