Biological Changes Induced by Physical Activity in Individuals with Down’s Syndrome

The effects of exercise and of a physical conditioning program on 11 subjects (7 males, 4 females, aged 15 to 20) with Down’s syndrome (DS) were analyzed. Metabolic responses were evaluated before and after two ergometric cycle exercise tests: an incremental exercise to symptom limited VO2 max. and an endurance test performed at 60% of maximal aerobic power. Plasma substrates, electrolytes, catecholamines, lipoprotein lipid profiles, and superoxide dismutase were assayed immediately before and after these tests. The results indicated (a) a low blood lactate level for peak exercise, (b) slow free fatty acid mobilization at the start of exercise, (c) a low level of cholesterol HDL and a high level of pre-beta VLDL at rest, (d) adjustment to nearly normal lipid profiles with endurance activity, and (e) differences between before and after training for superoxide dismutase levels in subjects with DS. These results suggest that endurance training could have long-term effects on the pathophysiological consequences of DS.

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Immunochemical quantification of Cu/Zn superoxide dismutase in prenatal diagnosis of Down's syndrome

Human Genetics ◽

10.1007/bf00206762 ◽

1990 ◽

Vol 85 (3) ◽

pp. 362-366 ◽

Cited By ~ 7

Author(s):

Tomas Porstmann ◽

Roselotte Wietschke ◽

Günther Cobet ◽

Katja Lorenz ◽

Roland Grunow ◽

...

Keyword(s):

Superoxide Dismutase ◽

Prenatal Diagnosis ◽

Down's Syndrome ◽

Down’S Syndrome

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Comparison of Two Scales for Assessing Motor Development in Infants with down's Syndrome

The Occupational Therapy Journal of Research ◽

10.1177/153944928300300403 ◽

1983 ◽

Vol 3 (4) ◽

pp. 213-221 ◽

Cited By ~ 4

Author(s):

Joan Snyder Lydic ◽

Margaret A. Short ◽

David L. Nelson

Keyword(s):

Motor Development ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Motor Ability ◽

Before And After ◽

Partial Correlations ◽

Depth Study ◽

Movement Assessment ◽

Stability Results

The Peabody Developmental Scales (PDS) and the Movement Assessment of Infants (MAI) were examined for their abilities to detect subtle changes in motor development of infants with Down's syndrome Both assessments were administered to 10 infants before and after a 6-week period A t-test suggested that the MAI was sensitive to developmental changes in the subjects tested from initial test to follow-up. Similar testing using the PDS did not reveal significant differences in the scores, suggesting that the MAI was the more sensitive of the two instruments. When partial correlations were calculated for possible artifactual effects due to age, the MAI still demonstrated greater stability. Results indicate that, for infants with Down's syndrome, the MAI may be preferable to the PDS for detecting changes in motor ability over short periods. However, these results should be considered tentative until a more in-depth study is conducted using a larger number of subjects from a variety of clinical populations.

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Serial Microbiota Analysis after Fecal Microbiota Transplantation in a Child with Down's Syndrome

Journal of Pediatric Infectious Diseases ◽

10.1055/s-0037-1606330 ◽

2017 ◽

Vol 14 (03) ◽

pp. 136-139

Author(s):

Lisethe Meijer ◽

Clementien Vermont ◽

Andries Budding ◽

Chris Mulder ◽

Tim Meij ◽

...

Keyword(s):

Fecal Microbiota Transplantation ◽

Diversity Index ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Fecal Microbiota ◽

Recurrent Clostridium Difficile Infection ◽

Microbiota Analysis ◽

Before And After ◽

Immunocompromised State ◽

Over Time

AbstractFecal microbiota transplantation (FMT) is a very effective treatment for recurrent Clostridium difficile infection (CDI) in adults. However, there is a paucity of data on FMT in children and associated microbiome changes in this particular group. We describe a child with Down's syndrome and intracranial malignancy, who received FMT for recurrent CDI. Detailed microbiota analysis before and after FMT, and pre- and post-recurrence, linked to microbial communities in the donor feces showed that the patient developed a unique microbiota profile after FMT which was very stable over time despite CDI recurrence and subsequent fidaxomicin therapy. Bacteroidetes were stably acquired from donor feces, while Firmicutes, Actinobacteria, Fusobacteria, Verrucomicrobia, and Proteobacteria were unique to the patient. The diversity of microbiota of the patient increased from a Shannon diversity index of 2.08 pre-FMT to 3.12 post-FMT. Our findings underscore that patients with Down's syndrome may well tolerate and benefit from FMT even in a severely immunocompromised state.

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