Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

2012 ◽  
Vol 23 (4) ◽  
pp. 393-405 ◽  
Author(s):  
Dorota Kostrzewa-Nowak ◽  
Bohdan Bieg ◽  
Mark J.I. Paine ◽  
C. Roland Wolf ◽  
Jolanta Tarasiuk
Keyword(s):  
Cytochrome P450 ◽  
Multidrug Resistant ◽  
Structural Factors ◽  
Cytochrome P450 Reductase ◽  
Hl60 Cells ◽  
Nadph Cytochrome ◽  
P450 Reductase ◽  
Anthraquinone Derivatives ◽  
Nadph Cytochrome P450 Reductase

DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells

2017 ◽  
Vol 69 (1) ◽  
pp. 185-195 ◽  
Author(s):  
Wojciech Żwierełło ◽  
Agnieszka Maruszewska ◽  
Robert Nowak ◽  
Dorota Kostrzewa-Nowak ◽  
Jolanta Tarasiuk
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cytochrome P450 ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Cytochrome P450 Reductase ◽  
Nadph Cytochrome ◽  
P450 Reductase ◽  
Nadph Cytochrome P450 Reductase

Role of NADPH cytochrome P450 reductase in activation of RH1

2007 ◽  
Vol 60 (5) ◽  
pp. 713-723 ◽  
Author(s):  
Asher Begleiter ◽  
Marsha K. Leith ◽  
Daywin Patel ◽  
Brian B. Hasinoff
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Reductase ◽  
Nadph Cytochrome ◽  
P450 Reductase ◽  
Nadph Cytochrome P450 Reductase
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