A New Physiologically Based Pharmacokinetic Model for the Prediction of Gastrointestinal Drug Absorption: Translocation Model

Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2014.10.018 ◽

2015 ◽

Vol 67 ◽

pp. 32-44 ◽

Cited By ~ 14

Author(s):

Andrés Olivares-Morales ◽

Yoshiteru Kamiyama ◽

Adam S. Darwich ◽

Leon Aarons ◽

Amin Rostami-Hodjegan

Keyword(s):

Controlled Release ◽

Drug Absorption ◽

Pharmacokinetic Model ◽

Relative Bioavailability ◽

Oral Drug ◽

Physiologically Based ◽

Controlled Release Formulations ◽

The Impact

Physiologically-Based Pharmacokinetic Model on the Oral Drug Absorption in Roux-en-Y Gastric Bypass Bariatric Patients: Amoxicillin Tablet and Suspension

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b00870 ◽

2019 ◽

Vol 16 (12) ◽

pp. 5025-5034

Author(s):

Maiara Camotti Montanha ◽

Andréa Diniz ◽

Nuno Miguel Elvas Neves Silva ◽

Elza Kimura ◽

Paulo Paixão

Keyword(s):

Gastric Bypass ◽

Drug Absorption ◽

Pharmacokinetic Model ◽

Oral Drug ◽

Oral Drug Absorption ◽

Physiologically Based ◽

Bariatric Patients

Prediction of Free Drug Absorption in Cyclodextrin Formulation by a Modified Physiologically Based Pharmacokinetic Model and Phase Solubility 3-D Surface Graph

Pharmaceutical Research ◽

10.1007/s11095-021-03071-3 ◽

2021 ◽

Author(s):

Wei Wang ◽

Defang Ouyang

Keyword(s):

Drug Absorption ◽

Pharmacokinetic Model ◽

Free Drug ◽

Phase Solubility ◽

Surface Graph ◽

Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

10.26226/morressier.5971be87d462b80290b534f2 ◽

2017 ◽

Author(s):

F. Calisti

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based ◽

Paediatric Dose

Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime

Environmental Research ◽

10.1016/j.envres.2021.111287 ◽

2021 ◽

pp. 111287

Author(s):

Deepika Deepika ◽

Raju Prasad Sharma ◽

Marta Schuhmacher ◽

Vikas Kumar

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Perfluorooctane Sulfonate ◽

Physiologically Based ◽

Age Dependent

Human risk assessment of di-isobutyl phthalate through the application of a developed physiologically based pharmacokinetic model of di-isobutyl phthalate and its major metabolite mono-isobutyl phthalate

Archives of Toxicology ◽

10.1007/s00204-021-03057-5 ◽

2021 ◽

Author(s):

Seung-Hyun Jeong ◽

Ji-Hun Jang ◽

Hea-Young Cho ◽

Yong-Bok Lee

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Model ◽

Major Metabolite ◽

Human Risk Assessment ◽

Human Risk ◽

Physiologically‐Based Pharmacokinetic Model for Alectinib, Ruxolitinib, and Panobinostat in The Presence of Cancer, Renal Impairment, and Hepatic Impairment

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2282 ◽

2021 ◽

Author(s):

Mo'tasem M. Alsmadi

Keyword(s):

Renal Impairment ◽

Hepatic Impairment ◽

Pharmacokinetic Model ◽

Development of a Physiologically-Based Pharmacokinetic Model for Perchloroethylene Using Tissue Concentration-Time Data

Toxicology and Applied Pharmacology ◽

10.1006/taap.1994.1179 ◽

1994 ◽

Vol 128 (1) ◽

pp. 50-59 ◽

Cited By ~ 15

Author(s):

C.E. Dallas ◽

X.M. Chen ◽

K. Obarr ◽

S. Muralidhara ◽

P. Varkonyi ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Tissue Concentration ◽

Time Data ◽

Concentration Time ◽

Development of a Physiologically Based Pharmacokinetic Model for Estradiol in Rats and Humans: A Biologically Motivated Quantitative Framework for Evaluating Responses to Estradiol and Other Endocrine-Active Compounds

Toxicological Sciences ◽

10.1093/toxsci/69.1.60 ◽

2002 ◽

Vol 69 (1) ◽

pp. 60-78 ◽

Cited By ~ 37

Author(s):

D. R. Plowchalk

Keyword(s):

Pharmacokinetic Model ◽

Active Compounds ◽

Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model

Drug Metabolism and Disposition ◽

10.1124/dmd.114.060046 ◽

2014 ◽

Vol 43 (2) ◽

pp. 217-226 ◽

Cited By ~ 3

Author(s):

Kazuhiko Shirota ◽

Makoto Kaneko ◽

Makoto Sasaki ◽

Kouichi Minato ◽

Akira Fujikata ◽

...

Keyword(s):

P38 Mapk ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

P38 Mapk Inhibitor ◽

Mapk Inhibitor