Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions

In Silico Predictions of Partition Coefficients for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-8 ◽

2016 ◽

pp. 141-183

Author(s):

Kannan Krishnan ◽

Andy Nong ◽

Sami Haddad

Keyword(s):

In Silico ◽

Partition Coefficients ◽

Pharmacokinetic Models ◽

Physiologically Based ◽

In Silico Predictions

A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Journal of Pharmaceutical Sciences ◽

10.1002/(sici)1520-6017(200001)89:1<16::aid-jps3>3.0.co;2-e ◽

2000 ◽

Vol 89 (1) ◽

pp. 16-35 ◽

Cited By ~ 278

Author(s):

Patrick Poulin ◽

Frank‐Peter Theil

Keyword(s):

Drug Discovery ◽

Partition Coefficients ◽

A Priori ◽

Pharmacokinetic Models ◽

Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Cited By ~ 7

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Pesticide Exposures ◽

Application of the Tissue Composition–Based Model to Minipig for Predicting the Volume of Distribution at Steady State and Dermis-to-Plasma Partition Coefficients of Drugs Used in the Physiologically Based Pharmacokinetics Model in Dermatology

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2018.09.001 ◽

2019 ◽

Vol 108 (1) ◽

pp. 603-619 ◽

Cited By ~ 3

Author(s):

Patrick Poulin ◽

Severine H. Collet ◽

Nicolas Atrux-Tallau ◽

Jean-Michel Linget ◽

Laurent Hennequin ◽

...

Keyword(s):

Steady State ◽

Partition Coefficients ◽

Volume Of Distribution ◽

Tissue Composition ◽

Physiologically Based Pharmacokinetics ◽

Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Cited By ~ 5

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based ◽

In Vivo Extrapolation

Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-16 ◽

2006 ◽

pp. 301-348 ◽

Cited By ~ 2

Author(s):

Robert De Woskin ◽

Chadwick Thompson ◽

Weihsueh Chiu ◽

Paul Schlosser ◽

Carolyn Smallwood ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Integrated Risk ◽

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

The AAPS Journal ◽

10.1208/s12248-015-9796-7 ◽

2015 ◽

Vol 17 (5) ◽

pp. 1268-1279 ◽

Cited By ~ 9

Author(s):

Helen Musther ◽

Katherine L. Gill ◽

Manoranjenni Chetty ◽

Amin Rostami-Hodjegan ◽

Malcolm Rowland ◽

...

Keyword(s):

Sampling Site ◽

Pharmacokinetic Models ◽

Central Venous ◽

Physiologically Based ◽

The Right

Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology ◽

10.1016/b978-0-12-804239-7.00004-4 ◽

2017 ◽

pp. 51-65

Author(s):

Kannan Krishnan ◽

Sandrine Fleur Chebekoue

Keyword(s):

Pharmacokinetic Models ◽

Developmental Toxicology ◽

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0685-y ◽

2018 ◽

Vol 58 (2) ◽

pp. 235-262 ◽

Cited By ~ 10

Author(s):

Khaled Abduljalil ◽

Masoud Jamei ◽

Trevor N. Johnson

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based ◽

Fetal Organs