Activation of Peroxisome Proliferator-Activated Receptor γ Does Not Explain the Antiproliferative Activity of the Nonsteroidal Anti-Inflammatory Drug Indomethacin on Human Colorectal Cancer Cells

2003 ◽  
Vol 305 (2) ◽  
pp. 632-637 ◽  
Author(s):  
G. Hawcroft ◽  
S. H. Gardner ◽  
M. A. Hull
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Peroxisome Proliferator ◽  
Human Colorectal Cancer ◽  
Peroxisome Proliferator Activated Receptor ◽  
Inflammatory Drug ◽  
Colorectal Cancer Cells ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells

scholarly journals Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells

2017 ◽  
Vol 11 (2) ◽  
pp. 90 ◽  
Author(s):  
Jae Hoon Cha ◽  
Woo Kyoung Kim ◽  
Ae Wha Ha ◽  
Myung Hwan Kim ◽  
Moon Jeong Chang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells ◽  
Inflammatory Effect

scholarly journals Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells

2003 ◽  
Vol 374 (2) ◽  
pp. 481-488 ◽  
Author(s):  
Alun HUGHES ◽  
Nicholas I. SMITH ◽  
Heather M. WALLACE
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Cell Number ◽  
Human Colorectal Cancer ◽  
Morphological Examination ◽  
Drug Induced ◽  
Colorectal Cancer Cells ◽  
Polyamine Content ◽  
Anti Inflammatory ◽  
Human Colorectal Cancer Cells

Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition of ornithine decarboxylase (the first enzyme of the polyamine biosynthetic pathway), induction of polyamine oxidase and spermidine/spermine N1-acetyltransferase (the enzymes responsible for polyamine catabolism) and induction of polyamine export all contributed to the decreased intracellular polyamine content. Morphological examination of the cells showed typical signs of apoptosis, and this was confirmed by DNA fragmentation and measurement of caspase-3-like activity. Re-addition of spermidine to the cells partially prevented apoptosis and recovered the cell number. Thus polyamines appear to be an integral part of the signalling pathway mediating NSAID toxicity in human colorectal cancer cells, and may therefore also be important in cancer chemoprevention in humans.

Sign in / Sign up

Export Citation Format

Share Document