Edaravone, a Novel Free Radical Scavenger, Prevents Liver Injury and Mortality in Rats Administered Endotoxin

Non-alcoholic liver injury (NLI) is a common disease worldwide. Since free radical damage in the liver is a crucial initiator leading to diseases, scavenging excess free radicals has become an essential therapeutic strategy. To enhance the antioxidant capacity of histidine, we synthesized a protonated dimeric histidine, H-bihistidine, and investigated its anti-free radical potential in several free-radical-induced NLI. Results showed that H-bihistidine could strongly scavenge free radicals caused by H2O2, fatty acid, and CCl4, respectively, and recover cell viability in cultured hepatocytes. In the animal model of nonalcoholic fatty liver injury caused by high-fat diet, H-bihistidine reduced the contents of transaminases and lipids in serum, eliminated the liver’s fat accumulation, and decreased the oxidative damage. Moreover, H-bihistidine could rescue CCl4-induced liver injury and recover energy supply through scavenging free radicals. Moreover, liver fibrosis prepared by high-fat diet and CCl4 administration was significantly alleviated after H-bihistidine treatment. This study suggests a novel nonenzymatic free radical scavenger against NLI and, potentially, other free-radical-induced diseases.

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793 Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin

Hepatology ◽

10.1016/s0270-9139(03)80835-2 ◽

2003 ◽

Vol 38 ◽

pp. 543-543

Author(s):

H KONO ◽

M ASAKAWA ◽

H FUJII ◽

A MAKI ◽

H AMEMIYA ◽

...

Keyword(s):

Free Radical ◽

Liver Injury ◽

Free Radical Scavenger ◽

Radical Scavenger

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Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats

Journal of Hepatology ◽

10.1016/j.jhep.2004.09.018 ◽

2005 ◽

Vol 42 (1) ◽

pp. 94-101 ◽

Cited By ~ 64

Author(s):

Katsushige Tsuji ◽

A-Hon Kwon ◽

Hideyuki Yoshida ◽

Zeyu Qiu ◽

Masaki Kaibori ◽

...

Keyword(s):

Free Radical ◽

Liver Injury ◽

Partial Hepatectomy ◽

Free Radical Scavenger ◽

Radical Scavenger

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Protective effect of the free radical scavenger (edaravone) against the photochemically induced cerebral infarction in the mice

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0030 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S30-S30

Author(s):

Shinji Nakajima ◽

Syoujiroh Sawada ◽

Yuhji Morimoto ◽

Souichiroh Nomura

Keyword(s):

Free Radical ◽

Cerebral Infarction ◽

Protective Effect ◽

Free Radical Scavenger ◽

Radical Scavenger

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OPTIMASI KONDISI EKSTRAKSI SENYAWA AKTIF ANTIOKSIDAN DARI BIJI ANGGUR

Sains & Teknologi ◽

10.24123/jst.v3i2.2281 ◽

2019 ◽

Vol 3 (2) ◽

pp. 35

Author(s):

Kartini Kartini ◽

Azminah Azminah

Keyword(s):

Free Radical ◽

Optimum Condition ◽

Active Compound ◽

Grape Seed ◽

Free Radical Scavenger ◽

Water Bath ◽

Radical Scavenger ◽

Optimum Conditions ◽

Ethanolic Solution ◽

Reduced Pressure

In order to prepare standardized extract, optimization of extraction conditions of grape seed has been done. These conditions are type of menstrum (50, 70 and 96% of ethanolic solution), length of extraction (1, 2 and 4 hours) also method of evaporation (reduced pressure and opened air). Activity on free radical scavenger used as parameters to determine optimum conditions. Based on EC50 (concentration which scavenge 50% amount of free radical) can be concluded that optimum condition for extracting antioxidant active compound from grape seed are 70% ethanolic solution as menstrum, length of extraction 1 hour and evaporation on opened air use water bath.

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