Transcriptional Regulation of Human and Mouse Organic Anion Transporter 1 by Hepatocyte Nuclear Factor 1 α/β

2007 ◽  
Vol 324 (2) ◽  
pp. 784-790 ◽  
Author(s):  
Takami Saji ◽  
Ryota Kikuchi ◽  
Hiroyuki Kusuhara ◽  
Insook Kim ◽  
Frank J. Gonzalez ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Anion Transporter ◽  
Nuclear Factor 1 ◽  
Human And Mouse

The Human Organic Anion Transporter GenesOAT5andOAT7Are Transactivated by Hepatocyte Nuclear Factor-1α (HNF-1α)

2010 ◽  
Vol 78 (6) ◽  
pp. 1079-1087 ◽  
Author(s):  
Kerstin Klein ◽  
Christoph Jüngst ◽  
Jessica Mwinyi ◽  
Bruno Stieger ◽  
Franz Krempler ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Anion Transporter ◽  
Hepatocyte Nuclear Factor 1Α

Hepatocyte nuclear factor-4α regulates the human organic anion transporter 1 gene in the kidney

2007 ◽  
Vol 292 (6) ◽  
pp. F1819-F1826 ◽  
Author(s):  
Ken Ogasawara ◽  
Tomohiro Terada ◽  
Jun-ichi Asaka ◽  
Toshiya Katsura ◽  
Ken-ichi Inui
Keyword(s):  
Promoter Activity ◽  
Molecular Mechanisms ◽  
Organic Anion ◽  
Critical Role ◽  
Direct Repeat ◽  
Organic Anion Transporter ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Mobility Shift ◽  
Anion Transporter

Human organic anion transporter 1 (OAT1, SLC22A6), which is localized to the basolateral membranes of renal tubular epithelial cells, plays a critical role in the excretion of anionic compounds. OAT1 is regulated by various pathophysiological conditions, but little is known about the molecular mechanisms regulating the expression of OAT1. In the present study, we investigated the transcriptional regulation of OAT1 and found that hepatocyte nuclear factor (HNF)-4α markedly transactivated the OAT1 promoter. A deletion analysis of the OAT1 promoter suggested that the regions spanning −1191 to −700 base pairs (bp) and −140 to −79 bp were essential for the transactivation by HNF-4α. These regions contained a direct repeat separated by two nucleotides (DR-2), which is one of the consensus sequences binding to HNF-4α, and an inverted repeat separated by eight nucleotides (IR-8), which was recently identified as a novel element for HNF-4α, respectively. An electrophoretic mobility shift assay showed that HNF-4α bound to DR-2 and IR-8 under the conditions of HNF-4α overexpression. Furthermore, under normal conditions, HNF-4α bound to IR-8, and a mutation in IR-8 markedly reduced the OAT1 promoter activity, indicating that HNF-4α regulates the basal transcription of OAT1 via IR-8. This paper reports the first characterization of the human OAT1 promoter and the first gene in the kidney whose promoter activity is regulated by HNF-4α.

Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1α/β and DNA Methylation

2006 ◽  
Vol 70 (3) ◽  
pp. 887-896 ◽  
Author(s):  
Ryota Kikuchi ◽  
Hiroyuki Kusuhara ◽  
Naka Hattori ◽  
Kunio Shiota ◽  
Insook Kim ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Anion Transporter ◽  
Hepatocyte Nuclear Factor 1Α ◽  
Organic Anion Transporter 3

The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α and Suppressed by Bile Acids

2005 ◽  
Vol 67 (5) ◽  
pp. 1629-1638 ◽  
Author(s):  
Katrin Popowski ◽  
Jyrki J. Eloranta ◽  
Michael Saborowski ◽  
Michael Fried ◽  
Peter J. Meier ◽  
...  
Keyword(s):  
Bile Acids ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Anion Transporter ◽  
Hepatocyte Nuclear Factor 4Α

scholarly journals Cloning and characterization of organic anion transporter 2 from human and mouse

2000 ◽  
Vol 82 ◽  
pp. 155
Author(s):  
Naomi Ohshiro ◽  
Yasuna Kobayashi ◽  
Shogo Tokuyama ◽  
Takashi Sekine ◽  
Hitoshi Endo ◽  
...  
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter ◽  
Human And Mouse

scholarly journals Transcriptional regulation of renal organic anion transporter 1 by B‐cell CLL/lymphoma 6 (892.33)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Maja Henjakovic ◽  
Waja Wegner ◽  
Birgitta Burckhardt ◽  
Gerhard Burckhardt
Keyword(s):  
Transcriptional Regulation ◽  
B Cell ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Anion Transporter

scholarly journals Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Takuya Watanabe ◽  
Atsushi Ozawa ◽  
Shinnosuke Masuda ◽  
Satoshi Yoshino ◽  
Emi Ishida ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Murine Liver ◽  
Nuclear Factor 1
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