The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma

2006 ◽  
Vol 70 (6) ◽  
pp. 2108-2115 ◽  
Author(s):  
Jun Fang ◽  
Quintin J. Quinones ◽  
Trevor L. Holman ◽  
Michael J. Morowitz ◽  
Qun Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Therapeutic Target ◽  
Monocarboxylate Transporter ◽  
Potential Therapeutic Target

HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort

Oncogene ◽  
2021 ◽  
Author(s):  
Elyse C. Page ◽  
Susan L. Heatley ◽  
Laura N. Eadie ◽  
Barbara J. McClure ◽  
Charles E. de Bock ◽  
...  
Keyword(s):  
Down Syndrome ◽  
High Risk ◽  
Significant Role ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
High Risk Cohort

349 Monocarboxylate transporter 1 as a potential therapeutic target in glioblastomas

2010 ◽  
Vol 8 (7) ◽  
pp. 111
Author(s):  
V. Gonçalves ◽  
C. Pinheiro ◽  
M. Honavar ◽  
P. Costa ◽  
R. Reis ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Monocarboxylate Transporter ◽  
Potential Therapeutic Target ◽  
Monocarboxylate Transporter 1

scholarly journals CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia

Oncotarget ◽  
2013 ◽  
Vol 4 (9) ◽  
pp. 1438-1448 ◽  
Author(s):  
Audrey Astori ◽  
Hanne Fredly ◽  
Thomas Aquinas Aloysius ◽  
Lars Bullinger ◽  
Véronique Mansat-De Mas ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
High Risk ◽  
Therapeutic Target ◽  
Myeloid Leukemia ◽  
Nuclear Factor ◽  
Potential Therapeutic Target ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase

2020 ◽  
Vol 6 (6) ◽  
pp. 416-421
Author(s):  
David Van Ly ◽  
Duo Wang ◽  
Robert Max Conway ◽  
Michael Giblin ◽  
Sharron Liang ◽  
...  
Keyword(s):  
High Risk ◽  
Uveal Melanoma ◽  
Therapeutic Target ◽  
Mevalonate Pathway ◽  
Lipid Production ◽  
Published Data ◽  
Potential Therapeutic Target ◽  
Hmg Coa Reductase ◽  
Coa Reductase

Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.

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