Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor-γ Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Skin Repair

Dana Schiefelbein; Oliver Seitz; Itamar Goren; Jan Philipp Dißmann; Helmut Schmidt; Malte Bachmann; Robert Sader; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank

doi:10.1124/mol.108.049395

Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor-γ Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Skin Repair

Molecular Pharmacology ◽

10.1124/mol.108.049395 ◽

2008 ◽

Vol 74 (4) ◽

pp. 952-963 ◽

Cited By ~ 17

Author(s):

Dana Schiefelbein ◽

Oliver Seitz ◽

Itamar Goren ◽

Jan Philipp Dißmann ◽

Helmut Schmidt ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Peroxisome Proliferator ◽

Vascular Endothelial ◽

Peroxisome Proliferator Activated Receptor ◽

Skin Repair ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal Pathways

Molecular Pharmacology ◽

10.1124/mol.110.063586 ◽

2010 ◽

Vol 78 (1) ◽

pp. 142-150 ◽

Cited By ~ 22

Author(s):

Chun-Ki Kim ◽

Yoon Kyung Choi ◽

Hansoo Lee ◽

Kwon-Soo Ha ◽

Moo-Ho Won ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Signal Pathways ◽

Vascular Endothelial ◽

Phosphatidylinositol 3 Kinase ◽

Farnesyltransferase Inhibitor ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Vascular endothelial growth factor protects motoneurons from serum deprivation–induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition

Neuroscience ◽

10.1016/j.neuroscience.2008.10.060 ◽

2009 ◽

Vol 158 (4) ◽

pp. 1348-1355 ◽

Cited By ~ 29

Author(s):

L. Tolosa ◽

M. Mir ◽

G. Olmos ◽

J. Lladó

Keyword(s):

Vascular Endothelial Growth Factor ◽

Cell Death ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Phosphatidylinositol 3 Kinase ◽

Protein Kinase Inhibition ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts Involvement of p38 mitogen-activated protein kinase

Cellular Signalling ◽

10.1016/s0898-6568(00)00061-9 ◽

2000 ◽

Vol 12 (6) ◽

pp. 375-380 ◽

Cited By ~ 24

Author(s):

Osamu Kozawa ◽

Hidenori Kawamura ◽

Daijiro Hatakeyama ◽

Hiroyuki Matsuno ◽

Toshihiko Uematsu

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Endothelin 1 ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Combined prescription (OAH19T) of Aralia cordata Thunb and Cimicifuga heracleifolia Komar and its major compounds inhibit matrix proteinases and vascular endothelial growth factor through the regulation of mitogen-activated protein kinase pathway

Journal of Ethnopharmacology ◽

10.1016/j.jep.2011.03.031 ◽

2011 ◽

Vol 135 (2) ◽

pp. 414-421 ◽

Cited By ~ 4

Author(s):

Jeong-Eun Huh ◽

Yae-Ji Shin ◽

Yong-Hyeon Baek ◽

Jae-Dong Lee ◽

Do-Young Choi ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Aralia Cordata ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor ◽

Kinase Pathway

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Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase

FEBS Letters ◽

10.1016/s0014-5793(97)01481-6 ◽

1997 ◽

Vol 420 (1) ◽

pp. 28-32 ◽

Cited By ~ 187

Author(s):

Caroline Wheeler-Jones ◽

Robin Abu-Ghazaleh ◽

Rosario Cospedal ◽

Rebecca A Houliston ◽

John Martin ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Endothelial Cells ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Cytosolic Phospholipase ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor ◽

Prostacyclin Production

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Mitogen-activated protein kinase, ERK1/2, is essential for the induction of vascular endothelial growth factor by ionizing radiation mediated by activator protein-1 in human glioblastoma cells

Free Radical Research ◽

10.1080/10715760000300711 ◽

2000 ◽

Vol 33 (2) ◽

pp. 157-166 ◽

Cited By ~ 23

Author(s):

Katsuharu Mori ◽

Masaharu Tani ◽

Kensaku Kamata ◽

Hideki Kawamura ◽

Yoshishige Urata ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Ionizing Radiation ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Activator Protein 1 ◽

Glioblastoma Cells ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Basic Fibroblast Growth Factor Stimulates Vascular Endothelial Growth Factor Release in Osteoblasts: Divergent Regulation by p42/p44 Mitogen-Activated Protein Kinase and p38 Mitogen-Activated Protein Kinase

Journal of Bone and Mineral Research ◽

10.1359/jbmr.2000.15.12.2371 ◽

2000 ◽

Vol 15 (12) ◽

pp. 2371-2379 ◽

Cited By ~ 44

Author(s):

Haruhiko Tokuda ◽

Osamu Kozawa ◽

Toshihiko Uematsu

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Mitogen Activated Protein ◽

Growth Factor Release ◽

Endothelial Growth Factor ◽

Factor Release

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Magnolol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-Dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways

Nutrition and Cancer ◽

10.1080/01635581.2013.828082 ◽

2013 ◽

Vol 65 (8) ◽

pp. 1245-1253 ◽

Cited By ~ 11

Author(s):

Ki Mo Kim ◽

No Soo Kim ◽

Jinhee Kim ◽

Jong-Shik Park ◽

Jin Mu Yi ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Signaling Pathways ◽

Akt Signaling ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Phosphatidylinositol 3 Kinase ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Ionizing radiation modulates vascular endothelial growth factor (VEGF) expression through multiple mitogen activated protein kinase dependent pathways

Oncogene ◽

10.1038/sj.onc.1204258 ◽

2001 ◽

Vol 20 (25) ◽

pp. 3266-3280 ◽

Cited By ~ 82

Author(s):

Jong-Sung Park ◽

Liang Qiao ◽

Zao-Zong Su ◽

Darin Hinman ◽

Karen Willoughby ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Ionizing Radiation ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Vegf Expression ◽

Mitogen Activated Protein ◽

Endothelial Growth Factor

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Mitogen-Activated Protein Kinase Phosphatase-1 Is a Key Regulator of Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Vessel Density in Lung

American Journal Of Pathology ◽

10.1016/j.ajpath.2010.11.025 ◽

2011 ◽

Vol 178 (1) ◽

pp. 98-109 ◽

Cited By ~ 10

Author(s):

Kristin M. Shields ◽

Evgeniy Panzhinskiy ◽

Nana Burns ◽

W. Michael Zawada ◽

Mita Das

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Protein Kinase ◽

Vessel Density ◽

Mitogen Activated Protein Kinase ◽

Vascular Endothelial ◽

Factor Expression ◽

Mitogen Activated Protein ◽

Growth Factor Expression ◽

Endothelial Growth Factor

Download Full-text