Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins, Adrenergic and Adenosine Receptors

Class A ◽

Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01453 ◽

2017 ◽

Vol 61 (1) ◽

pp. 1-46 ◽

Cited By ~ 39

Author(s):

Yoonji Lee ◽

Shaherin Basith ◽

Sun Choi

Keyword(s):

Drug Design ◽

Crystal Structures ◽

G Protein ◽

Computational Simulations ◽

Structure Based Drug Design ◽

Class A ◽

Recent Advances ◽

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

PLoS ONE ◽

10.1371/journal.pone.0138463 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138463 ◽

Cited By ~ 53

Author(s):

Adam L. Martin ◽

Michael A. Steurer ◽

Robert S. Aronstam

Keyword(s):

G Protein ◽

Constitutive Activity ◽

Class A ◽

FoldGPCR: Structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.22731 ◽

2010 ◽

Vol 78 (10) ◽

pp. 2189-2201 ◽

Cited By ~ 26

Author(s):

Mayako Michino ◽

Jianhan Chen ◽

Raymond C. Stevens ◽

Charles L. Brooks

Keyword(s):

G Protein ◽

Structure Prediction ◽

Transmembrane Domain ◽

Class A ◽

Frontispiece: Universality of the Sodium Ion Binding Mechanism in Class A G-Protein-Coupled Receptors

Angewandte Chemie International Edition ◽

10.1002/anie.201881261 ◽

2018 ◽

Vol 57 (12) ◽

Author(s):

Balaji Selvam ◽

Zahra Shamsi ◽

Diwakar Shukla

Keyword(s):

G Protein ◽

Sodium Ion ◽

Ion Binding ◽

Binding Mechanism ◽

Class A ◽

Homology Modeling of Class A G-Protein-Coupled Receptors in the Age of the Structure Boom

Methods in Molecular Biology - Computational Design of Membrane Proteins ◽

10.1007/978-1-0716-1468-6_5 ◽

2021 ◽

pp. 73-97

Author(s):

Asma Tiss ◽

Rym Ben Boubaker ◽

Daniel Henrion ◽

Hajer Guissouma ◽

Marie Chabbert

Keyword(s):

Homology Modeling ◽

G Protein ◽

Class A ◽

Importance of protein dynamics in the structure-based drug discovery of class A G protein-coupled receptors (GPCRs)

Current Opinion in Structural Biology ◽

10.1016/j.sbi.2019.03.015 ◽

2019 ◽

Vol 55 ◽

pp. 147-153 ◽

Cited By ~ 12

Author(s):

Yoonji Lee ◽

Raudah Lazim ◽

Stephani Joy Y Macalino ◽

Sun Choi

Keyword(s):

Drug Discovery ◽

Protein Dynamics ◽

G Protein ◽

Class A ◽

Universality of the Sodium Ion Binding Mechanism in Class A G-Protein-Coupled Receptors

Angewandte Chemie ◽

10.1002/ange.201708889 ◽

2018 ◽

Vol 130 (12) ◽

pp. 3102-3107 ◽

Cited By ~ 9

Author(s):

Balaji Selvam ◽

Zahra Shamsi ◽

Diwakar Shukla

Keyword(s):

G Protein ◽

Sodium Ion ◽

Ion Binding ◽

Binding Mechanism ◽

Class A ◽

G protein-coupled receptors of class A harness the energy of membrane potential to increase their sensitivity and selectivity

Biochimica et Biophysica Acta (BBA) - Biomembranes ◽

10.1016/j.bbamem.2019.183051 ◽

2019 ◽

Vol 1861 (12) ◽

pp. 183051 ◽

Cited By ~ 4

Author(s):

Daria N. Shalaeva ◽

Dmitry A. Cherepanov ◽

Michael Y. Galperin ◽

Gert Vriend ◽

Armen Y. Mulkidjanian

Keyword(s):

Membrane Potential ◽

G Protein ◽

Class A ◽

Sensitivity And Selectivity ◽

An Indel in Transmembrane Helix 2 Helps to Trace the Molecular Evolution of Class A G-Protein-Coupled Receptors

Journal of Molecular Evolution ◽

10.1007/s00239-009-9214-9 ◽

2009 ◽

Vol 68 (5) ◽

pp. 475-489 ◽

Cited By ~ 23

Author(s):

Julie Devillé ◽

Julien Rey ◽

Marie Chabbert

Keyword(s):

Molecular Evolution ◽

G Protein ◽

Transmembrane Helix ◽

Class A ◽

GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

BMC Bioinformatics ◽

10.1186/s12859-015-0639-4 ◽

2015 ◽

Vol 16 (1) ◽

Cited By ~ 10

Author(s):

Santiago Rios ◽

Marta F. Fernandez ◽

Gianluigi Caltabiano ◽

Mercedes Campillo ◽

Leonardo Pardo ◽

...

Keyword(s):

Amino Acid ◽

G Protein ◽

Amino Acid Substitution ◽

Substitution Matrix ◽

Transmembrane Region ◽

Class A ◽

Amino Acid Substitution Matrix ◽