The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Differentiation and Apoptosis in Human Leukemia K562 Cells

Brian B. Hasinoff; Michael E. Abram; Norman Barnabé; Tayeb Khélifa; William P. Allan; Jack C. Yalowich

doi:10.1124/mol.59.3.453

The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Differentiation and Apoptosis in Human Leukemia K562 Cells

Molecular Pharmacology ◽

10.1124/mol.59.3.453 ◽

2001 ◽

Vol 59 (3) ◽

pp. 453-461 ◽

Cited By ~ 41

Author(s):

Brian B. Hasinoff ◽

Michael E. Abram ◽

Norman Barnabé ◽

Tayeb Khélifa ◽

William P. Allan ◽

...

Keyword(s):

Topoisomerase Ii ◽

K562 Cells ◽

Human Leukemia ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor ◽

Catalytic Dna ◽

Human Leukemia K562 Cells

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4-Methyl-7-(tetradecanoyl)-2H-1-benzopyran-2-one: a novel DNA topoisomerase II inhibitor with adulticidal and embryostatic activity against sub-periodic Brugia malayi

Parasitology Research ◽

10.1007/s00436-003-1014-3 ◽

2004 ◽

Vol 92 (3) ◽

pp. 177-182 ◽

Cited By ~ 20

Author(s):

Shailja Misra-Bhattacharya ◽

Diksha Katiyar ◽

Preeti Bajpai ◽

R.P. Tripathi ◽

J.K. Saxena

Keyword(s):

Topoisomerase Ii ◽

Brugia Malayi ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor

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Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone

Tetrahedron ◽

10.1016/j.tet.2008.01.112 ◽

2008 ◽

Vol 64 (21) ◽

pp. 4827-4834 ◽

Cited By ~ 20

Author(s):

Prabhakar Bachu ◽

Jonathan Sperry ◽

Margaret A. Brimble

Keyword(s):

Protease Inhibitor ◽

Topoisomerase Ii ◽

Chemoenzymatic Synthesis ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor ◽

3C Protease

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HY-2, a novel DNA topoisomerase II inhibitor, induces G2/M cell cycle arrest in HCT-116 cells

Journal of Chemotherapy ◽

10.1179/1973947813y.0000000153 ◽

2013 ◽

Vol 26 (6) ◽

pp. 342-347 ◽

Cited By ~ 2

Author(s):

Zhonghua Wu ◽

Yu Zhao ◽

Yuting Zhang ◽

Li Zhu

Keyword(s):

Cell Cycle ◽

Cell Cycle Arrest ◽

Topoisomerase Ii ◽

Dna Topoisomerase Ii ◽

M Cell ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor ◽

Cycle Arrest ◽

Hct 116 ◽

Hct 116 Cells

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DNA Topoisomerase II Inhibition by Peroxisomicine A1and Its Radical Metabolite Induces Apoptotic Cell Death of HL-60 and HL-60/MX2 Human Leukemia Cells

Chemical Research in Toxicology ◽

10.1021/tx000145j ◽

2001 ◽

Vol 14 (1) ◽

pp. 16-24 ◽

Cited By ~ 8

Author(s):

Amélie Lansiaux ◽

William Laine ◽

Brigitte Baldeyrou ◽

Christine Mahieu ◽

Nicole Wattez ◽

...

Keyword(s):

Cell Death ◽

Topoisomerase Ii ◽

Apoptotic Cell ◽

Apoptotic Cell Death ◽

Leukemia Cells ◽

Human Leukemia ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Human Leukemia Cells

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Cellular Resistance to the Antitumor DNA Topoisomerase II Inhibitor S16020-2: Importance of the N-[2(Dimethylamino)ethyl]carbamoyl Side Chain

Molecular Pharmacology ◽

10.1124/mol.58.4.709 ◽

2000 ◽

Vol 58 (4) ◽

pp. 709-718 ◽

Cited By ~ 5

Author(s):

Sandrine Le Mée ◽

Françoise Chaminade ◽

Charlotte Delaporte ◽

Judith Markovits ◽

Jean-Marie Saucier ◽

...

Keyword(s):

Topoisomerase Ii ◽

Side Chain ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Cellular Resistance ◽

Topoisomerase Ii Inhibitor

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hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide

Molecular Pharmacology ◽

10.1124/mol.119.118315 ◽

2019 ◽

Vol 97 (3) ◽

pp. 159-170 ◽

Cited By ~ 2

Author(s):

Evan E. Kania ◽

Jessika Carvajal-Moreno ◽

Victor A. Hernandez ◽

Anthony English ◽

Jonathan L. Papa ◽

...

Keyword(s):

Acquired Resistance ◽

K562 Cells ◽

Human Leukemia ◽

Topoisomerase Iiα ◽

Dna Topoisomerase ◽

Transcriptional Modulators ◽

Human Leukemia K562 Cells ◽

Dna Topoisomerase Iiα

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ChemInform Abstract: Chemoenzymatic Synthesis of Deoxy Analogues of the DNA Topoisomerase II Inhibitor Eleutherin and the 3C-Protease Inhibitor Thysanone.

ChemInform ◽

10.1002/chin.200839205 ◽

2008 ◽

Vol 39 (39) ◽

Author(s):

Prabhakar Bachu ◽

Jonathan Sperry ◽

Margaret A. Brimble

Keyword(s):

Protease Inhibitor ◽

Topoisomerase Ii ◽

Chemoenzymatic Synthesis ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor ◽

3C Protease

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ChemInform Abstract: Podophyllotoxin Aza-Analogue, a Novel DNA Topoisomerase II Inhibitor.

ChemInform ◽

10.1002/chin.200038248 ◽

2000 ◽

Vol 31 (38) ◽

pp. no-no

Author(s):

Akira Iida ◽

Masahiro Kano ◽

Yoshihiro Kubota ◽

Kenji Koga ◽

Kiyoshi Tomioka

Keyword(s):

Topoisomerase Ii ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor

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Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/j.mrgentox.2005.01.002 ◽

2005 ◽

Vol 582 (1-2) ◽

pp. 79-86 ◽

Cited By ~ 29

Author(s):

A.J. Olaharski ◽

S.T. Mondrala ◽

D.A. Eastmond

Keyword(s):

Topoisomerase Ii ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Topoisomerase Ii Inhibitor ◽

Micronucleus Induction

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Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA

Biochemistry ◽

10.1021/bi00469a028 ◽

1990 ◽

Vol 29 (17) ◽

pp. 4235-4241 ◽

Cited By ~ 50

Author(s):

Daniel J. Fernandes ◽

Mary K. Danks ◽

William T. Beck

Keyword(s):

Nuclear Matrix ◽

Topoisomerase Ii ◽

Leukemia Cells ◽

Human Leukemia ◽

Dna Topoisomerase Ii ◽

Dna Topoisomerase ◽

Human Leukemia Cells

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