The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2003 ◽  
Vol 63 (6) ◽  
pp. 1256-1272 ◽  
Author(s):  
Robert Fredriksson ◽  
Malin C. Lagerström ◽  
Lars-Gustav Lundin ◽  
Helgi B. Schiöth
Keyword(s):  
Phylogenetic Analysis ◽  
Human Genome ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

scholarly journals Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

Genomics ◽  
2006 ◽  
Vol 88 (3) ◽  
pp. 263-273 ◽  
Author(s):  
Thóra K. Bjarnadóttir ◽  
David E. Gloriam ◽  
Sofia H. Hellstrand ◽  
Helena Kristiansson ◽  
Robert Fredriksson ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled ◽  
Human And Mouse

scholarly journals Understanding the Added Value of G-Protein-Coupled Receptor Heteromers

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Nuria Franco ◽  
Rafael Franco
Keyword(s):  
Human Genome ◽  
G Protein ◽  
Nobel Prize ◽  
Basic Research ◽  
G Protein Coupled Receptors ◽  
Added Value ◽  
G Protein Coupled Receptor ◽  
Receptor Heteromers ◽  
The Future ◽  
G Protein Coupled

G-protein-coupled receptors (GPCRs) constitute the most populated family of proteins within the human genome. Since the early sixties work on GPCRs and on GPCR-mediated signaling has led to a number of awards, the most recent being the Nobel Prize in Chemistry for 2012. The future of GPCRs research is surely based on their capacity for heteromerization. Receptor heteromers offer a series of challenges that will help in providing success in academic/basic research and translation into more effective and safer drugs.

Sign in / Sign up

Export Citation Format

Share Document