Characterization of VU0468554, a new selective inhibitor of cardiac GIRK channels

2021 ◽  
pp. MOLPHARM-AR-2021-000311
Author(s):  
Allison Anderson ◽  
Baovi N Vo ◽  
Ezequiel Marron Fernandez de Velasco ◽  
Corey R. Hopkins ◽  
C. David Weaver ◽  
...  
Keyword(s):  
Selective Inhibitor ◽  
Girk Channels

scholarly journals Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

2014 ◽  
Vol 463 (3) ◽  
pp. 413-427 ◽  
Author(s):  
Ruzica Bago ◽  
Nazma Malik ◽  
Michael J. Munson ◽  
Alan R. Prescott ◽  
Paul Davies ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Selective Inhibitor ◽  
Class Iii ◽  
Phosphate Binding ◽  
Downstream Target ◽  
Phosphoinositide 3 Kinase ◽  
Phosphatidylinositol 3

We characterize VPS34-IN, a potent and selective inhibitor of class III Vps34 PI3K. Using VPS34-IN1, we demonstrate that PtdIns(3)P, produced by Vps34 controls phosphorylation and activity of the SGK3 protein kinase.

Abstract P251: Discovery and characterization of RLY-2608: The first allosteric, mutant, and isoform-selective inhibitor of PI3Kα

2021 ◽  
Author(s):  
Ermira Pazolli ◽  
Randy Kipp ◽  
Alessandro Boezio ◽  
Hakan Gunaydin ◽  
Amanda Iskandar ◽  
...  
Keyword(s):  
Selective Inhibitor

scholarly journals Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent

2012 ◽  
Vol 2 (5) ◽  
pp. 425-433 ◽  
Author(s):  
Jing Ni ◽  
Qingsong Liu ◽  
Shaozhen Xie ◽  
Coby Carlson ◽  
Thanh Von ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Functional Characterization ◽  
Selective Inhibitor

Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay

2017 ◽  
Vol 12 (7) ◽  
pp. 1760-1768 ◽  
Author(s):  
Misa Iwatani-Yoshihara ◽  
Masahiro Ito ◽  
Yoshihiro Ishibashi ◽  
Hideyuki Oki ◽  
Toshio Tanaka ◽  
...  
Keyword(s):  
Mrna Decay ◽  
Selective Inhibitor ◽  
Initiation Factor ◽  
Eukaryotic Initiation Factor ◽  
Nonsense Mediated Mrna Decay

Abstract B235: Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity.

2011 ◽  
Author(s):  
Robert M. Campbell ◽  
Bryan D. Anderson ◽  
Edward M. Chan ◽  
Alfonso De Dios ◽  
Raymond Gilmour ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
P38 Mapk ◽  
Selective Inhibitor

Abstract A230: Discovery and characterization of ARQ 092, an ATP-independent, potent and selective inhibitor of AKT kinases.

2011 ◽  
Author(s):  
Thomas C.K. Chan ◽  
Jean-Marc Lapierre ◽  
Mark A. Ashwell ◽  
Dennis S. France ◽  
Chang-Rung Chen ◽  
...  
Keyword(s):  
Selective Inhibitor

Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

MedChemComm ◽  
2014 ◽  
Vol 5 (9) ◽  
pp. 1381-1383 ◽  
Author(s):  
Derong Ding ◽  
Katerina Lichtenwalter ◽  
Hualiang Pi ◽  
Shahriar Mobashery ◽  
Mayland Chang
Keyword(s):  
Matrix Metalloproteinase ◽  
Broad Spectrum ◽  
Selective Inhibitor ◽  
Mmp Inhibitor

MMP-8 has been implicated in various diseases using a reported selective MMP-8 inhibitor that is actually a broad-spectrum MMP inhibitor.

scholarly journals Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases

2009 ◽  
Vol 284 (16) ◽  
pp. 10571-10582 ◽  
Author(s):  
Usha Padmanabhan ◽  
D. Eric Dollins ◽  
Peter C. Fridy ◽  
John D. York ◽  
C. Peter Downes
Keyword(s):  
Selective Inhibitor ◽  
Inositol Hexakisphosphate
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