scholarly journals Distinct plasma immune signatures in ME/CFS are present early in the course of illness

2015 ◽  
Vol 1 (1) ◽  
pp. e1400121 ◽  
Author(s):  
Mady Hornig ◽  
José G. Montoya ◽  
Nancy G. Klimas ◽  
Susan Levine ◽  
Donna Felsenstein ◽  
...  
Keyword(s):  
Regulatory Networks ◽  
Chronic Fatigue ◽  
The United States ◽  
Sample Collection ◽  
Course Of Illness ◽  
Illness Duration ◽  
Fatigue Syndrome ◽  
Immune Signatures ◽  
Duration Of Illness ◽  
Relationship Of

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained incapacitating illness that may affect up to 4 million people in the United States alone. There are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. We considered the possibility that inability to identify such biomarkers reflected variations in diagnostic criteria and laboratory methods as well as the timing of sample collection during the course of the illness. Accordingly, we leveraged two large, multicenter cohort studies of ME/CFS to assess the relationship of immune signatures with diagnosis, illness duration, and other clinical variables. Controls were frequency-matched on key variables known to affect immune status, including season of sampling and geographic site, in addition to age and sex. We report here distinct alterations in plasma immune signatures early in the course of ME/CFS (n= 52) relative to healthy controls (n= 348) that are not present in subjects with longer duration of illness (n= 246). Analyses based on disease duration revealed that early ME/CFS cases had a prominent activation of both pro- and anti-inflammatory cytokines as well as dissociation of intercytokine regulatory networks. We found a stronger correlation of cytokine alterations with illness duration than with measures of illness severity, suggesting that the immunopathology of ME/CFS is not static. These findings have critical implications for discovery of interventional strategies and early diagnosis of ME/CFS.

scholarly journals Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review

Diagnostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 91 ◽  
Author(s):  
Mateo Cortes Rivera ◽  
Claudio Mastronardi ◽  
Claudia Silva-Aldana ◽  
Mauricio Arcos-Burgos ◽  
Brett Lidbury
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Age Of Onset ◽  
Chronic Fatigue ◽  
The United States ◽  
Myalgic Encephalomyelitis ◽  
World Health ◽  
Fatigue Syndrome ◽  
Control And Prevention ◽  
The Moment ◽  
Health Organization

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology that is recognized by the World Health Organization (WHO) and the United States Center for Disease Control and Prevention (US CDC) as a disorder of the brain. The disease predominantly affects adults, with a peak age of onset of between 20 and 45 years with a female to male ratio of 3:1. Although the clinical features of the disease have been well established within diagnostic criteria, the diagnosis of ME/CFS is still of exclusion, meaning that other medical conditions must be ruled out. The pathophysiological mechanisms are unclear but the neuro-immuno-endocrinological pattern of CFS patients gleaned from various studies indicates that these three pillars may be the key point to understand the complexity of the disease. At the moment, there are no specific pharmacological therapies to treat the disease, but several studies’ aims and therapeutic approaches have been described in order to benefit patients’ prognosis, symptomatology relief, and the recovery of pre-existing function. This review presents a pathophysiological approach to understanding the essential concepts of ME/CFS, with an emphasis on the population, clinical, and genetic concepts associated with ME/CFS.

scholarly journals Illness Duration and Coping Style in Chronic Fatigue Syndrome

2010 ◽  
Vol 106 (2) ◽  
pp. 383-393 ◽  
Author(s):  
Molly M. Brown ◽  
Abigail A. Brown ◽  
Leonard A. Jason
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Coping Strategies ◽  
Symptom Severity ◽  
Coping Styles ◽  
Chronic Fatigue ◽  
Lower Percentage ◽  
Physical Impairment ◽  
Illness Duration ◽  
Fatigue Syndrome ◽  
Long Duration

A sample of patients with chronic fatigue syndrome was recruited to assess coping strategies and illness duration. It was hypothesized that adaptive coping strategies would be higher among those with longer illness duration. Those in the longer illness duration group reported higher use of active coping, positive reframing, planning, and acceptance, and lower use of behavioral disengagement than those in the shorter illness duration group. No significant differences were found between the two illness duration groups for physical impairment or symptom severity, but the long duration group revealed a lower percentage of participants who were working than the short duration group. These findings suggest that individuals with longer or shorter duration of the illness have differences in coping styles but not differences in physical impairment or symptom severity.

scholarly journals A Rose By Any Other Name?

2016 ◽  
Vol 10 (4) ◽  
Author(s):  
Richard Marlin PhD
Keyword(s):  
United States ◽  
Chronic Fatigue Syndrome ◽  
Diagnostic Criteria ◽  
Functional Impairment ◽  
Chronic Fatigue ◽  
The United States ◽  
Myalgic Encephalomyelitis ◽  
Expert Committee ◽  
Institute Of Medicine ◽  
Fatigue Syndrome

In February of this year, an expert committee of the United States Institute of Medicine (IOM) released a lengthy report in which its members reviewed diagnostic criteria and proposed a new label for chronic fatigue syndrome, also historically referred to as myalgic encephalomyelitis.1 The committee’s proposed new label for this illness is Systemic Exertion Intolerance Disease. The report refers to the fact that a sizeable population is diagnosed with this illness, which causes considerable suffering and functional impairment. Many patients also feel stigmatized because of the label chronic fatigue syndrome.

Illness duration, mood and symptom impact in adolescents with chronic fatigue syndrome/myalgic encephalomyelitis?

2019 ◽  
Vol 105 (9) ◽  
pp. 911-912
Author(s):  
Francesca K Neale ◽  
Deborah Christie ◽  
Dougal S Hargreaves ◽  
Terry Y Segal
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Illness Duration ◽  
Fatigue Syndrome

scholarly journals The Relationship between Age and Illness Duration in Chronic Fatigue Syndrome

Diagnostics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 16 ◽  
Author(s):  
Elizabeth Kidd ◽  
Abigail Brown ◽  
Stephanie McManimen ◽  
Leonard Jason ◽  
Julia Newton ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Illness Duration ◽  
Fatigue Syndrome ◽  
The Relationship

scholarly journals A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome

2013 ◽  
Vol 14 (1) ◽  
pp. 29 ◽  
Author(s):  
Anne Smylie ◽  
Gordon Broderick ◽  
Henrique Fernandes ◽  
Shirin Razdan ◽  
Zachary Barnes ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Gulf War ◽  
Gulf War Illness ◽  
Fatigue Syndrome ◽  
Immune Signatures

The Relationship of Fennell Phases to Symptoms Among Patients With Chronic Fatigue Syndrome

2009 ◽  
Vol 32 (3) ◽  
pp. 264-280 ◽  
Author(s):  
Nadia L. Reynolds ◽  
Molly M. Brown ◽  
Leonard A. Jason
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Relationship Of ◽  
The Relationship

scholarly journals Analysis of the Causal Relationship of Body Image Factors in Patients with Cancer

2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Vita Ari Fatmawati ◽  
Christantie Effendy ◽  
Ridho Rahmadi
Keyword(s):  
Body Image ◽  
Causal Model ◽  
Cognitive Factors ◽  
Causal Relationships ◽  
Affective Factors ◽  
Illness Duration ◽  
Patients With Cancer ◽  
Duration Of Illness ◽  
Negative Impacts ◽  
Relationship Of

Patients with cancer can potentially experience the negative impacts of treatment. Physical conditions due to illness and therapy can affect the patient's body image. This study aims to find a causal model among body image factors of patients with cancer using the S3C-Latent Method. The measurement of body image of patients with cancer used the BIS questionnaire. One hundred and ninety-nine patients with cancer participated in this study. The results showed the existence of causal relationships between behavior to cognitive factors and duration of illness with reliability scores of 0.8 and 0.6, respectively; from gender to affective factors, illness duration, behavior, and cognitive factors with reliability scores of 0.6, 0.8, 0.65, and 1, respectively. There are also causal relationships from age to affective factors, duration of illness, and cognitive factors with reliability scores of 0.8, 0.7, and 0.9, respectively. The results also showed that affective factors are associated with behavior, cognitive factors, and duration of illness, with reliability scores of 1, 1, and 0.9, respectively. The results showed further the association of cognitive factors and illness duration with a reliability score of 1. We expect that the estimated causal model will serve as a scientific reference for medical experts in developing a better intervention such as treatment.

scholarly journals Hypothesis: Neuroglia Activation due to Increased Peripheral and CNS Proinflammatory Cytokines/Chemokines with Neuroinflammation May Result in Long COVID

Neuroglia ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 7-35
Author(s):  
Melvin R. Hayden
Keyword(s):  
Metabolic Stress ◽  
Chronic Fatigue ◽  
The United States ◽  
Common Denominator ◽  
Stress Injury ◽  
Fatigue Syndrome ◽  
Obesity And Diabetes ◽  
Transmission Electron ◽  
Spanish Flu ◽  
Historical Accounts

The COVID-19 pandemic has paralleled the great Spanish flu pandemic of 1918–1919 in the United States. Previous historical accounts have strongly suggested a post-viral syndrome and, currently, a post-COVID-19 viral syndrome is unquestionable, which shares many of the characteristics of myalgic encephalomyelitis/chronic fatigue syndrome that is present globally. The original term for this post-acute sequela of SARS-CoV-2 (PASC) was termed long haulers by those who were affected with this syndrome and it is now termed long COVID (LC) or PASC. International researchers and clinicians are desperately trying to better understand the pathobiological mechanisms possibly involved in this syndrome. This review aims to summarize many of the cumulated findings associated with LC/PASC and provides supportive and representative illustrations and transmission electron micrographic remodeling changes within brain tissues associated with a stress type of injury as occurs in the classic db/db and novel BTBR ob/ob obesity and diabetes mellitus mice models. These models are utilized to merely provide a response to metabolic stress injury wound healing mechanisms that are also present in humans. This review posits that neuroglial activation and chronic neuroinflammation may be a common denominator for the development of the complex LC/PASC syndrome following acute COVID-19 due to SARS-CoV-2.

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