Opioid signaling rewards steroid abuse

Science ◽  
2020 ◽  
Vol 369 (6508) ◽  
pp. 1203.7-1204
Author(s):  
Leslie K. Ferrarelli
Keyword(s):  
Steroid Abuse ◽  
Opioid Signaling

Tuning Down the Pain – An Overview of Allosteric Modulation of Opioid Receptors: Mechanisms of Modulation, Allosteric Sites, Modulator Syntheses

2020 ◽  
Vol 20 (31) ◽  
pp. 2852-2865 ◽  
Author(s):  
Damian Bartuzi ◽  
Tomasz M. Wróbel ◽  
Agnieszka A. Kaczor ◽  
Dariusz Matosiuk
Keyword(s):  
Side Effects ◽  
Opioid Receptors ◽  
Pain Perception ◽  
Allosteric Modulation ◽  
Allosteric Modulators ◽  
Signaling Mechanisms ◽  
Main Target ◽  
Allosteric Sites ◽  
Biased Signaling ◽  
Opioid Signaling

Opioid signaling plays a central role in pain perception. As such, it remains the main target in the development of antinociceptive agents, despite serious side effects involved. In recent years, hopes for improved opioid painkillers are rising, together with our understanding of allosterism and biased signaling mechanisms. In this review, we focus on recently discovered allosteric modulators of opioid receptors, insights into phenomena underlying their action, as well as on how they extend our understanding of mechanisms of previously known compounds. A brief overlook of their synthesis is also presented.

Prolonged impairment of sexual function associated with anabolic–androgenic steroid abuse: An underrecognized problem

2014 ◽  
Vol 94 (2) ◽  
pp. 237
Author(s):  
Harrison G. Pope ◽  
Gen Kanayama ◽  
James I. Hudson ◽  
James DeLuca ◽  
Stephanie Isaacs ◽  
...  
Keyword(s):  
Sexual Function ◽  
Anabolic Androgenic Steroid ◽  
Steroid Abuse ◽  
Androgenic Steroid

scholarly journals Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification

2013 ◽  
Vol 63 (3) ◽  
pp. 207-215 ◽  
Author(s):  
Lixin Kan ◽  
Amelia A. Mutso ◽  
Tammy L. McGuire ◽  
Apkar Vania Apkarian ◽  
John A. Kessler
Keyword(s):  
Mast Cells ◽  
Heterotopic Ossification ◽  
Opioid Signaling
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