Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring

Science ◽  
2021 ◽  
Vol 373 (6558) ◽  
Author(s):  
Ai Ing Lim ◽  
Taryn McFadden ◽  
Verena M. Link ◽  
Seong-Ji Han ◽  
Rose-Marie Karlsson ◽  
...  
Keyword(s):  
Maternal Infection ◽  
Tissue Specific ◽  
Specific Immunity

Tissue-specific immunity for a changing world

Cell ◽  
2021 ◽  
Vol 184 (6) ◽  
pp. 1517-1529
Author(s):  
Stuart P. Weisberg ◽  
Basak B. Ural ◽  
Donna L. Farber
Keyword(s):  
Tissue Specific ◽  
Specific Immunity ◽  
Changing World

Progression of Alloresponse and Tissue-Specific Immunity during Graft Coronary Artery Disease

2005 ◽  
Vol 5 (6) ◽  
pp. 1286-1296 ◽  
Author(s):  
Masashi Tanaka ◽  
Monika Zwierzchoniewska ◽  
Golnaz K. Mokhtari ◽  
Raya D. Terry ◽  
Leora B. Balsam ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Tissue Specific ◽  
Specific Immunity ◽  
Artery Disease

scholarly journals Tissue-Specific Immunity in Homeostasis and Diseases

2019 ◽  
Vol 2019 ◽  
pp. 1-2
Author(s):  
Ning Wu ◽  
Erwei Sun ◽  
Dongfang Liu ◽  
Di Yu
Keyword(s):  
Tissue Specific ◽  
Specific Immunity

scholarly journals Maternal infection promotes offspring tissue-specific immune fitness

2021 ◽  
Author(s):  
Ai Ing Lim ◽  
Taryn McFadden ◽  
Verena M. Link ◽  
Seong-Ji Han ◽  
Rose-Marie Karlsson ◽  
...  
Keyword(s):  
Immune System ◽  
Epithelial Cells ◽  
Protective Immunity ◽  
Developmental Stages ◽  
Intestinal Epithelial ◽  
Maternal Infection ◽  
Tissue Specific ◽  
The Face ◽  
Mammalian Immune System

AbstractThe mammalian immune system has evolved in the face of microbial exposure. How maternal infection experienced at distinct developmental stages shapes the offspring immune system remains poorly understood. Here we show that during pregnancy, maternally restricted infection can have permanent and tissue-specific impacts on offspring immunity. Mechanistically, maternal IL-6 produced in response to infection can specifically and directly impose epigenetic changes on fetal intestinal epithelial cells. Such imprinting is associated with long-lasting impacts on intestinal immune homeostasis, characterized by enhanced tonic immunity to the microbiota and heightened Th17 responses within the gut, but not at other barrier sites. Furthermore, the offspring from IL-6-exposed dams developed enhanced protective immunity to gastrointestinal infection. Together, this work demonstrates that maternal infection experienced during pregnancy can be coopted by the fetus to promote long-term tissue-specific fitness.Summary sentenceInfection-induced maternal IL-6 impacts offspring epithelial cells, resulting in heightened immunity to the microbiota and pathogens.

scholarly journals Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

Cell ◽  
2015 ◽  
Vol 163 (2) ◽  
pp. 354-366 ◽  
Author(s):  
Denise Morais da Fonseca ◽  
Timothy W. Hand ◽  
Seong-Ji Han ◽  
Michael Y. Gerner ◽  
Arielle Glatman Zaretsky ◽  
...  
Keyword(s):  
Acute Infection ◽  
Tissue Specific ◽  
Specific Immunity

scholarly journals Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity

Cell Research ◽  
2020 ◽  
Vol 30 (6) ◽  
pp. 475-491 ◽  
Author(s):  
Christoph S. N. Klose ◽  
David Artis
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Tissue Specific ◽  
Specific Immunity
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