scholarly journals Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4

2020 ◽  
Vol 13 (615) ◽  
pp. eaba1302 ◽  
Author(s):  
Tammie Bishop ◽  
Peter J. Ratcliffe

The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.

Chemoecology ◽  
2011 ◽  
Vol 22 (1) ◽  
pp. 23-28 ◽  
Author(s):  
József Vuts ◽  
Till Tolasch ◽  
Lorenzo Furlan ◽  
Éva Bálintné Csonka ◽  
Tamás Felföldi ◽  
...  

1990 ◽  
Vol 265 (13) ◽  
pp. 7687-7692
Author(s):  
M Yamada ◽  
N Amuro ◽  
Y Goto ◽  
T Okazaki

1997 ◽  
Vol 44 (5) ◽  
pp. 477-491 ◽  
Author(s):  
Wei Wu ◽  
Morris Goodman ◽  
Margaret I. Lomax ◽  
Lawrence I. Grossman

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