Bioassay for Determining Voriconazole Serum Levels in Patients Receiving Combination Therapy with Echinocandins
2015 ◽
Vol 60
(1)
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pp. 632-636
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ABSTRACTVoriconazole levels were determined with high-performance liquid chromatography (HPLC) and a microbiological agar diffusion assay using aCandida parapsilosisisolate in 103 serum samples from an HPLC-tested external quality control program (n= 39), 21 patients receiving voriconazole monotherapy (n= 39), and 7 patients receiving combination therapy (n= 25). The results of the bioassay were correlated with the results obtained from the external quality control program samples and with the HPLC results in sera from patients on voriconazole monotherapy and on combination therapy with an echinocandin (Spearman's rank correlation coefficient [rs], > 0.93; mean ± standard error of the mean [SEM] % difference, <12% ± 3.8%).
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2002 ◽
Vol 44
(5)
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pp. 431-436
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1983 ◽
Vol 18
(5)
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pp. 1150-1159
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1980 ◽
Vol 26
(11)
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pp. 1607-1609
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2010 ◽
Vol 14
(2)
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pp. 175-181
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2005 ◽
Vol 22
(11-12)
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pp. 379-387
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