scholarly journals Pharmacokinetics of Ofloxacin and Levofloxacin for Prevention and Treatment of Multidrug-Resistant Tuberculosis in Children

2014 ◽  
Vol 58 (5) ◽  
pp. 2948-2951 ◽  
Author(s):  
S. Thee ◽  
A. J. Garcia-Prats ◽  
H. M. McIlleron ◽  
L. Wiesner ◽  
S. Castel ◽  
...  
2019 ◽  
Vol 6 ◽  
pp. 204993611986473 ◽  
Author(s):  
Julie Huynh ◽  
Ben J. Marais

The World Health Organization estimates that 10 million new cases of tuberculosis (TB) occurred worldwide in 2017, of which 600,000 were rifampicin or multidrug-resistant (RR/MDR) TB. Modelling estimates suggest that 32,000 new cases of MDR-TB occur in children annually, but only a fraction of these are correctly diagnosed and treated. Accurately diagnosing TB in children, who usually have paucibacillary disease, and implementing effective TB prevention and treatment programmes in resource-limited settings remain major challenges. In light of the underappreciated RR/MDR-TB burden in children, and the lack of paediatric data on newer drugs for TB prevention and treatment, we present an overview of new and repurposed TB drugs, describing the available evidence for safety and efficacy in children to assist clinical care and decision-making.


1996 ◽  
Vol 21 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Neil W. Schluger ◽  
Robert M. Lawrence ◽  
Georgeann McGuiness ◽  
Maryann Park ◽  
William N. Rom

2011 ◽  
Vol 54 (2) ◽  
pp. 157-166 ◽  
Author(s):  
J. A. Seddon ◽  
A. C. Hesseling ◽  
M. Willemse ◽  
P. R. Donald ◽  
H. S. Schaaf

2017 ◽  
Vol 107 (11) ◽  
pp. 983 ◽  
Author(s):  
G B Firth ◽  
J Lescheid ◽  
M Camacho ◽  
M Esteves ◽  
N Beylis ◽  
...  

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