The K101P and K103R/V179D Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nonnucleoside Reverse Transcriptase Inhibitors
2006 ◽
Vol 50
(1)
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pp. 351-354
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Keyword(s):
ABSTRACT Genotypic patterns associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in the absence of well-characterized resistance mutations were identified using a database (n > 47,000) of phenotype-genotype data. Among samples with no known NNRTI mutations, the most resistant samples contained K101P (n = 35) or a combination of K103R and V179D (n = 41). Site-directed mutagenesis confirmed the importance of these mutations.
2019 ◽
Vol 9
(2)
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pp. 261-264
Keyword(s):
2006 ◽
Vol 80
(9)
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pp. 4440-4446
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2012 ◽
Vol 56
(6)
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pp. 3324-3335
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1998 ◽
Vol 14
(3)
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pp. 255-260
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2008 ◽
Vol 53
(2)
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pp. 487-495
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1993 ◽
Vol 37
(5)
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pp. 947-949
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2010 ◽
Vol 54
(5)
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pp. 1973-1980
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