scholarly journals Searches among mycobacterial cultures for antileprosy vaccines

1980 ◽  
Vol 29 (3) ◽  
pp. 1034-1039 ◽  
Author(s):  
C C Shepard ◽  
R van Landingham ◽  
L L Walker
Keyword(s):  
Lymph Nodes ◽  
Mycobacterium Bovis ◽  
Mycobacterium Leprae ◽  
Regional Lymph Nodes ◽  
Vaccine Protection ◽  
Mycobacterium Bovis Bcg ◽  
Vaccine Site

All mycobacteria species share some antigens, so there may be cultivable mycobacterial cultures that can provide vaccine protection against leprosy. Vaccine protection against Mycobacterium leprae infections in mice has been demonstrated for M. leprae itself, as living or heat-killed suspensions, and for Mycobacterium bovis (BCG), as living suspensions. Results are reported here with 17 other cultures. The mycobacterial suspensions were injected intradermally, and the mice were challenged in the footpad with infectious suspensions of M. leprae. In two experiments the mice were also challenged by footpad injections of 10(7) heat-killed M. leprae so the footpad enlargment could be measured. That some mycobacterial suspensions were immunogenic for some of their own antigens was suggested by reactions at the vaccine site and enlargement of the regional lymph nodes. Some mycobacterial suspensions also stimulated footpad enlargement on challenge by homologous suspensions or by challenge with M. leprae suspensions. Consistent protection against infectious challenge with M. leprae was observed only with BCG and M. leprae, however.

Intracellular signals triggered during association of Mycobacterium leprae and Mycobacterium bovis BCG with human monocytes

2001 ◽  
Vol 31 (1) ◽  
pp. 37-45 ◽  
Author(s):  
C.S. Lima ◽  
M.L. Ribeiro ◽  
L.A. Souza ◽  
A.B. Sardella ◽  
V.M.A. Wolf ◽  
...  
Keyword(s):  
Mycobacterium Bovis ◽  
Mycobacterium Leprae ◽  
Human Monocytes ◽  
Mycobacterium Bovis Bcg ◽  
Intracellular Signals

scholarly journals The Bovine Tuberculoid Granuloma

Pathogens ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 61
Author(s):  
Mitchell V. Palmer ◽  
Carly Kanipe ◽  
Paola M. Boggiatto
Keyword(s):  
Lymph Nodes ◽  
Disease Severity ◽  
Mycobacterium Bovis ◽  
Vaccine Efficacy ◽  
Bovine Tuberculosis ◽  
Regional Lymph Nodes ◽  
Cytokines And Chemokines ◽  
Successful Control ◽  
Bacterial Replication ◽  
Efficacy Studies

The bovine tuberculoid granuloma is the hallmark lesion of bovine tuberculosis (bTB) due to Mycobacterium bovis infection. The pathogenesis of bTB, and thereby the process of bovine tuberculoid granuloma development, involves the recruitment, activation, and maintenance of cells under the influence of antigen, cytokines and chemokines in affected lungs and regional lymph nodes. The granuloma is key to successful control of bTB by preventing pathogen dissemination through containment by cellular and fibrotic layers. Paradoxically, however, it may also provide a niche for bacterial replication. The morphologic and cellular characteristics of granulomas have been used to gauge disease severity in bTB pathogenesis and vaccine efficacy studies. As such, it is critical to understand the complex mechanisms behind granuloma initiation, development, and maintenance.

Sign in / Sign up

Export Citation Format

Share Document