scholarly journals Cross-reactive lymphocyte responses and protective immunity against other spotted fever group rickettsiae in mice immunized with Rickettsia conorii.

1986 ◽  
Vol 51 (3) ◽  
pp. 832-837 ◽  
Author(s):  
T R Jerrells ◽  
D L Jarboe ◽  
C S Eisemann
2016 ◽  
Vol 7 (1) ◽  
pp. 150-153 ◽  
Author(s):  
Mariana Ionita ◽  
Cornelia Silaghi ◽  
Ioan Liviu Mitrea ◽  
Sophie Edouard ◽  
Philippe Parola ◽  
...  

Parasitology ◽  
2017 ◽  
Vol 144 (8) ◽  
pp. 1088-1101 ◽  
Author(s):  
JESSICA ROSE ◽  
YAARIT NACHUM-BIALA ◽  
KOSTA Y. MUMCUOGLU ◽  
MOH A. ALKHAMIS ◽  
ADI BEN-NUN ◽  
...  

SUMMARYThis study aimed to genetically characterize spotted fever group rickettsiae (SFGR) in questing ixodid ticks from Israel and to identify risk factors associated with SFGR-positive ticks using molecular techniques and geographic information systems (GIS) analysis. 1039 ticks from the genusRhipicephaluswere collected during 2014. 109/1039 (10·49%) carried SFGR-DNA of eitherRickettsia massiliae(95), ‘CandidatusRickettsia barbariae’ (8) orRickettsia conorii(6). Higher prevalence of SFGR was found inRhipicephalus turanicus(18·00%) compared withRhipicephalus sanguineussensu lato (3·22%).Rickettsia massiliaewas the most commonly detected species and the most widely disseminated throughout Israel (87·15% of allRickettsia-positive ticks). GIS analysis revealed that Central and Northern coastal regions are at high risk for SFGR. The presence of ticks was significantly associated with normalized difference vegetation index and temperature variation over the course of the year. The presence of rickettsiae was significantly associated with brown type soils, higher land surface temperature and higher precipitation. The latter parameters may contribute to infection of the tick with SFGR. Health care professionals should be aware of the possible exposure of local communities and travellers toR. massillae. Molecular and geographical information can help professionals to identify areas that are susceptible to SFGR-infected ticks.


2000 ◽  
Vol 51 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Hiromi FUJITA ◽  
Nobuhiro TAKADA ◽  
Emiko ISOGAI ◽  
Yuriko WATANABE ◽  
Takuya ITO

2014 ◽  
Vol 52 (11) ◽  
pp. 3960-3966 ◽  
Author(s):  
M. F. Vaughn ◽  
J. Delisle ◽  
J. Johnson ◽  
G. Daves ◽  
C. Williams ◽  
...  

Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 228
Author(s):  
M. Nathan Kristof ◽  
Paige E. Allen ◽  
Lane D. Yutzy ◽  
Brandon Thibodaux ◽  
Christopher D. Paddock ◽  
...  

Rickettsia are significant sources of tick-borne diseases in humans worldwide. In North America, two species in the spotted fever group of Rickettsia have been conclusively associated with disease of humans: Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, and Rickettsia parkeri, the cause of R. parkeri rickettsiosis. Previous work in our lab demonstrated non-endothelial parasitism by another pathogenic SFG Rickettsia species, Rickettsia conorii, within THP-1-derived macrophages, and we have hypothesized that this growth characteristic may be an underappreciated aspect of rickettsial pathogenesis in mammalian hosts. In this work, we demonstrated that multiple other recognized human pathogenic species of Rickettsia, including R. rickettsii, R. parkeri, Rickettsia africae, and Rickettsiaakari can grow within target endothelial cells as well as within PMA-differentiated THP-1 cells. In contrast, Rickettsia bellii, a Rickettsia species not associated with disease of humans, and R. rickettsii strain Iowa, an avirulent derivative of pathogenic R. rickettsii, could invade both cell types but proliferate only within endothelial cells. Further analysis revealed that similar to previous studies on R. conorii, other recognized pathogenic Rickettsia species could grow within the cytosol of THP-1-derived macrophages and avoided localization with two different markers of lysosomal compartments; LAMP-2 and cathepsin D. R. bellii, on the other hand, demonstrated significant co-localization with lysosomal compartments. Collectively, these findings suggest that the ability of pathogenic rickettsial species to establish a niche within macrophage-like cells could be an important factor in their ability to cause disease in mammals. These findings also suggest that analysis of growth within mammalian phagocytic cells may be useful to predict the pathogenic potential of newly isolated and identified Rickettsia species.


2018 ◽  
Vol 24 (11) ◽  
pp. 2105-2107 ◽  
Author(s):  
Xuhong Yin ◽  
Shengchun Guo ◽  
Chunlian Ding ◽  
Minzhi Cao ◽  
Hiroki Kawabata ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document