scholarly journals Tumor necrosis factor alpha binding to bacteria: evidence for a high-affinity receptor and alteration of bacterial virulence properties.

1993 ◽  
Vol 61 (3) ◽  
pp. 830-835 ◽  
Author(s):  
G Luo ◽  
D W Niesel ◽  
R A Shaban ◽  
E A Grimm ◽  
G R Klimpel
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Bacterial Virulence ◽  
Necrosis Factor Alpha ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Factor Alpha ◽  
Affinity Receptor ◽  
Necrosis Factor ◽  
Virulence Properties

Tumor Necrosis Factor (TNF)-Soluble High-Affinity Receptor Complex as a TNF Antagonist

2007 ◽  
Vol 322 (2) ◽  
pp. 822-828 ◽  
Author(s):  
Sean D. McKenna ◽  
Georg Feger ◽  
Christie Kelton ◽  
Meijia Yang ◽  
Vittoria Ardissone ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Receptor Complex ◽  
High Affinity ◽  
Tnf Antagonist ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS

2000 ◽  
Vol 275 (45) ◽  
pp. 35478-35485 ◽  
Author(s):  
Youmei Wu ◽  
Dana Bressette ◽  
Jeff A. Carrell ◽  
Thomas Kaufman ◽  
Ping Feng ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Family Members ◽  
Tnf Receptor ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Necrosis Factor

scholarly journals The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration

1993 ◽  
Vol 90 (23) ◽  
pp. 11137-11141 ◽  
Author(s):  
E I Korpelainen ◽  
J R Gamble ◽  
W B Smith ◽  
G J Goodall ◽  
S Qiyu ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Tnf Alpha ◽  
Scatchard Analysis ◽  
Necrosis Factor Alpha ◽  
High Affinity ◽  
Factor Alpha ◽  
Necrosis Factor

Interleukin (IL)-3 stimulates hemopoiesis in vitro. However, IL-3 is not normally found in bone marrow, raising doubts as to the in vivo role of IL-3. We have found that human umbilical vein endothelial cells (HUVEC) express functional high-affinity receptors for IL-3 after stimulation with tumor necrosis factor alpha (TNF-alpha), IL-1 beta, or lipopolysaccharide, and that this receptor is involved in inflammatory phenomena. TNF-alpha caused time- and dose-dependent up-regulation of mRNA for the IL-3 receptor alpha and beta chains, with maximal effects occurring 16-36 h after stimulation with TNF-alpha at 100 units/ml. Induction of mRNA correlated with protein expression on the cell surface as judged by monoclonal antibody staining and by the ability of HUVEC to specifically bind 125I-labeled IL-3. Scatchard analysis under optimal conditions of TNF-alpha stimulation revealed approximately 1500 IL-3 receptors per cell, which were of a high-affinity class (Kd = 500 pM) only. In contrast to a previous report, receptors for granulocyte-macrophage colony-stimulating factor could not be detected. IL-3 binding to TNF-alpha-activated HUVEC enhanced IL-8 production, E-selection expression, and neutrophil transmigration. The selective induction of a functional IL-3 receptor on endothelial cells suggests that, beyond hemopoiesis, IL-3 may have an important role in chronic inflammation and in allergic diseases.

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