scholarly journals The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

1998 ◽  
Vol 95 (2) ◽  
pp. 570-575 ◽  
Author(s):  
M. Grell ◽  
H. Wajant ◽  
G. Zimmermann ◽  
P. Scheurich
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Necrosis Factor

Tumor Necrosis Factor (TNF)-Soluble High-Affinity Receptor Complex as a TNF Antagonist

2007 ◽  
Vol 322 (2) ◽  
pp. 822-828 ◽  
Author(s):  
Sean D. McKenna ◽  
Georg Feger ◽  
Christie Kelton ◽  
Meijia Yang ◽  
Vittoria Ardissone ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Receptor Complex ◽  
High Affinity ◽  
Tnf Antagonist ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS

2000 ◽  
Vol 275 (45) ◽  
pp. 35478-35485 ◽  
Author(s):  
Youmei Wu ◽  
Dana Bressette ◽  
Jeff A. Carrell ◽  
Thomas Kaufman ◽  
Ping Feng ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Family Members ◽  
Tnf Receptor ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Necrosis Factor

scholarly journals Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor

Blood ◽  
2005 ◽  
Vol 106 (13) ◽  
pp. 4241-4248 ◽  
Author(s):  
Hajime Nishimoto ◽  
Seung-Woo Lee ◽  
Hong Hong ◽  
Karen G. Potter ◽  
Mari Maeda-Yamamoto ◽  
...  
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cytokine Production ◽  
Immunoglobulin E ◽  
Tumor Necrosis Factor Receptor ◽  
Protein Levels ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Necrosis Factor

Mast cells are the major effector-cell type for immediate hypersensitivity and other forms of allergic reactions. Expression of 4-1BB, a member of the tumor necrosis factor receptor superfamily, is induced at mRNA and protein levels on stimulation through the high-affinity receptor for immunoglobulin E (IgE; FcϵRI). In this study, we present evidence that agonistic anti-4-1BB antibodies can enhance FcϵRI-induced cytokine production and secretion. Consistent with this, 4-1BB-deficient mast cells exhibit reduced degranulation and cytokine production on FcϵRI stimulation. Analysis of 4-1BB ligand (4-1BBL)-deficient cells supported this notion. As a potential mechanism for these defects, we identified a defect in Ca2+ flux induced by FcϵRI stimulation. The defective Ca2+ flux could be accounted for by the reduced activity of Lyn/Btk/phospholipase C-γ2 pathway and constitutive interactions between 4-1BB and Lyn. Therefore, FcϵRI-inducible 4-1BB plays a costimulatory function together with FcϵRI stimulation.

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and CD56 Expression in Patients With Type 1 Diabetes Mellitus

Pancreas ◽  
2005 ◽  
Vol 30 (2) ◽  
pp. 105-114 ◽  
Author(s):  
Sze-shuen C Cheung ◽  
Daniel L Metzger ◽  
Xiaojie Wang ◽  
Junqi Huang ◽  
Joseph Tai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Tumor Necrosis Factor ◽  
Type 1 Diabetes Mellitus ◽  
Tumor Necrosis ◽  
Cd56 Expression ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor α Is Associated With Viral Control and Early Disease Progression in Patients With HIV Type 1 Infection

2014 ◽  
Vol 210 (7) ◽  
pp. 1042-1046 ◽  
Author(s):  
Sagar A. Vaidya ◽  
Christian Korner ◽  
Michael N. Sirignano ◽  
Molly Amero ◽  
Sue Bazner ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Disease Progression ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Early Disease ◽  
Viral Control ◽  
Hiv Type 1 ◽  
Factor Α ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document