scholarly journals Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis.

1994 ◽  
Vol 62 (7) ◽  
pp. 2761-2772 ◽  
Author(s):  
A Louie ◽  
A L Baltch ◽  
R P Smith ◽  
M A Franke ◽  
W J Ritz ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Murine Model ◽  
Tumor Necrosis ◽  
Protective Role ◽  
Systemic Candidiasis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma

2009 ◽  
Vol 50 (4) ◽  
pp. 569 ◽  
Author(s):  
Hae-Seong Nam ◽  
Sook Young Lee ◽  
Seung Jun Kim ◽  
Ju Sang Kim ◽  
Soon Seog Kwon ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Airway Inflammation ◽  
Tumor Necrosis Factor Alpha ◽  
Murine Model ◽  
Tumor Necrosis ◽  
Acute Asthma ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production

2005 ◽  
Vol 73 (6) ◽  
pp. 3745-3748 ◽  
Author(s):  
Hongyan Diao ◽  
Masashi Kohanawa
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Protective Role ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Deficient Mice ◽  
Necrosis Factor

ABSTRACT During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-α) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-α monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-α production in S. pyogenes infection.

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