scholarly journals Recombinant Proteins of Cryptosporidium parvum Induce Proliferation of Mesenteric Lymph Node Cells in Infected Mice

2005 ◽  
Vol 73 (8) ◽  
pp. 5245-5248 ◽  
Author(s):  
Inderpal Singh ◽  
Cynthia Theodos ◽  
Saul Tzipori

ABSTRACT Recombinant antigens of Cryptosporidium parvum, Cp900 and Cp40 but not Cp15, stimulated C. parvum-specific proliferative immune responses of mesenteric lymph node cells in C57BL/6J mice infected with different isolates (MD, GCH1, UCP, and IOWA) of C. parvum, indicating that both Cp900 and Cp40 are immunodominant targets of cellular immune responses during C. parvum infection.

2001 ◽  
Vol 120 (5) ◽  
pp. A516-A516
Author(s):  
F HOENTJEN ◽  
S TONKONOGY ◽  
D SPRENGERS ◽  
M GOERRES ◽  
R SARTOR ◽  
...  

Vaccine ◽  
2018 ◽  
Vol 36 (22) ◽  
pp. 3090-3100 ◽  
Author(s):  
Axel T. Lehrer ◽  
Teri-Ann S. Wong ◽  
Michael M. Lieberman ◽  
Tom Humphreys ◽  
David E. Clements ◽  
...  

Parasitology ◽  
1977 ◽  
Vol 74 (3) ◽  
pp. 225-234 ◽  
Author(s):  
D. Wakelin ◽  
Margaret M. Wilson

When mice were irradiated immediately before infection withTrichinella spiralisthere was a profound and long-lasting interference with their ability to expel adult worms from the intestine. Irradiation given after the fifth day of infection was progressively less effective in this respect. The ability to expel worms was not restored when mesenteric lymph node cells (MLNC) were transferred (a) on the day of infection in mice irradiated one day previously, or (b) on day 7 of an infection in mice irradiated on day 6, even though the MLNC transferred immunity to intact recipients. Transfer of bone marrow (BM) alone was also without effect. However, worm explusion was restored if, following irradiation and injection of BM, 10 days were allowed for BM differentiation before transfer of MLNC. This restoration was effective even after lethal levels of irradiation and was clearly dependent upon a donor-derived BM component cooperating with, or responding to, the activity of the transferred MLNC. The possibility that the BM component is non-lymphoid in nature is discussed.


Metabolism ◽  
2000 ◽  
Vol 49 (9) ◽  
pp. 1111-1117 ◽  
Author(s):  
Fraser W. Scott ◽  
Elizabeth Olivares ◽  
Abdullah Sener ◽  
Willy J. Malaisse

2006 ◽  
Vol 143 (3) ◽  
pp. 474-483 ◽  
Author(s):  
F. Hoentjen ◽  
S. L. Tonkonogy ◽  
B. Liu ◽  
R. B. Sartor ◽  
J. D. Taurog ◽  
...  

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 381-389 ◽  
Author(s):  
T. D. G. Lee ◽  
R. K. Grencis ◽  
D. Wakelin

SUMMARYInfections with either 300 infective Trichinella spiralis larvae or 400 embryonated eggs of Trichuris muris were effective in eliciting accelerated expulsion of heterologous challenge infections given 20 days after the primary infection. Accelerated expulsion could also be achieved by the administration of soluble crude worm antigen given 12 days prior to heterologous challenge or by adoptive transfer of mesenteric lymph node cells taken from mice infected with the heterologous parasite. Each species is capable of eliciting an accelerated secondary expulsion response in hosts that have been actively or adoptively immunized against the other species and these results are taken to indicate that there is a specific cross-immunity between T. spiralis and T. muris due to shared antigens. It is postulated that these shared antigens are derived from stichocyte granules.


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