scholarly journals Microarray Analysis and Functional Characterization of the Nitrosative Stress Response in Nonmucoid and Mucoid Pseudomonas aeruginosa

2004 ◽  
Vol 186 (12) ◽  
pp. 4046-4050 ◽  
Author(s):  
Aaron M. Firoved ◽  
Simon R. Wood ◽  
Wojciech Ornatowski ◽  
Vojo Deretic ◽  
Graham S. Timmins

ABSTRACT The type strain of Pseudomonas aeruginosa, PAO1, showed great upregulation of many nitrosative defense genes upon treatment with S-nitrosoglutathione, while the mucoid strain PAO578II showed no further upregulation above its constitutive upregulation of nor and fhp. NO· consumption however, showed that both strains mount functional, protein synthesis-dependent NO·-consumptive responses.

2021 ◽  
Vol 183 ◽  
pp. 112610
Author(s):  
Xinhua Zhang ◽  
Jaime A. Teixeira da Silva ◽  
Meiyun Niu ◽  
Ting Zhang ◽  
Huanfang Liu ◽  
...  

2014 ◽  
Vol 196 (22) ◽  
pp. 3890-3902 ◽  
Author(s):  
O. Caille ◽  
D. Zincke ◽  
M. Merighi ◽  
D. Balasubramanian ◽  
H. Kumari ◽  
...  

2017 ◽  
Vol 67 (7) ◽  
pp. 459-468 ◽  
Author(s):  
Yan Wang ◽  
Maiqian Nie ◽  
Yi Wan ◽  
Xiaoting Tian ◽  
Hongyun Nie ◽  
...  

2020 ◽  
Vol 48 (11) ◽  
pp. 6157-6169 ◽  
Author(s):  
Elisa Vilardo ◽  
Fabian Amman ◽  
Ursula Toth ◽  
Annika Kotter ◽  
Mark Helm ◽  
...  

Abstract The TRM10 family of methyltransferases is responsible for the N1-methylation of purines at position 9 of tRNAs in Archaea and Eukarya. The human genome encodes three TRM10-type enzymes, of which only the mitochondrial TRMT10C was previously characterized in detail, whereas the functional significance of the two presumably nuclear enzymes TRMT10A and TRMT10B remained unexplained. Here we show that TRMT10A is m1G9-specific and methylates a subset of nuclear-encoded tRNAs, whilst TRMT10B is the first m1A9-specific tRNA methyltransferase found in eukaryotes and is responsible for the modification of a single nuclear-encoded tRNA. Furthermore, we show that the lack of G9 methylation causes a decrease in the steady-state levels of the initiator tRNAiMet-CAT and an alteration in its further post-transcriptional modification. Our work finally clarifies the function of TRMT10A and TRMT10B in vivo and provides evidence that the loss of TRMT10A affects the pool of cytosolic tRNAs required for protein synthesis.


2001 ◽  
Vol 40 (3) ◽  
pp. 708-718 ◽  
Author(s):  
Rahim Rahim ◽  
Urs A. Ochsner ◽  
Clarita Olvera ◽  
Michael Graninger ◽  
Paul Messner ◽  
...  

Gene ◽  
2007 ◽  
Vol 401 (1-2) ◽  
pp. 19-27 ◽  
Author(s):  
Fang Bai ◽  
Yingli Li ◽  
Haijing Xu ◽  
Huiming Xia ◽  
Tengfei Yin ◽  
...  

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