scholarly journals Prenatal Diagnosis of Congenital Cytomegalovirus Infection

1998 ◽  
Vol 36 (12) ◽  
pp. 3540-3544 ◽  
Author(s):  
T. Lazzarotto ◽  
B. Guerra ◽  
P. Spezzacatena ◽  
S. Varani ◽  
L. Gabrielli ◽  
...  
Keyword(s):  
At Risk ◽  
Prenatal Diagnosis ◽  
Predictive Value ◽  
Virus Isolation ◽  
First Trimester ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
First Trimester Of Pregnancy ◽  
Better Than

We report here the results of a study on the prenatal diagnosis of congenital cytomegalovirus (CMV) infection. The study was carried out by both PCR and virus isolation from amniotic fluid (AF) for 82 pregnant women at risk of transmitting CMV for the detection of (i) seroconversion to CMV immunoglobulin G (IgG) positivity during the first trimester of pregnancy, (ii) symptomatic CMV infection in the mother during the first trimester of pregnancy or intrauterine growth retardation detected by ultrasound or abnormal ultrasonographic findings suggestive of fetal infections, and (iii) seropositivity for CMV-specific IgM. For 50 women, fetal blood (FB) was also obtained and tests for antigenemia and PCR were performed. The results indicate that AF is better than FB for the prenatal diagnosis of CMV infection. PCR with AF has a sensitivity (SNS) of 100%, a specificity (SPE) of 83.3%, a positive predictive value (PPV) of 40%, and a negative predictive value (NPV) of 100%; rapid virus isolation with the same material has an SNS of 50%, an SPE of 100%, a PPV of 100%, and an NPV of 94.7%. Fewer than 10% of the women positive for IgM by enzyme immunoassay (EIA) had a congenitally infected fetus or newborn infant. When EIA IgM positivity was confirmed by Western blotting (WB) and the WB profile was considered, the percent transmission detected among women with an “at-risk” profile was higher than that observed among IgM-positive women and was the same as that among women who seroconverted during the first trimester of pregnancy (transmission rates of 29 and 25%, respectively).

scholarly journals Congenital cytomegalovirus infection: occurrence in two socioeconomically distinct populations of a developing country

1985 ◽  
Vol 27 (2) ◽  
pp. 105-108 ◽  
Author(s):  
Cláudio S. Pannuti ◽  
Lucy S. Vilas-boas ◽  
Maria J. O. Angelo ◽  
Renato P. S. Carvalho ◽  
Conceição M. Segre
Keyword(s):  
Umbilical Cord ◽  
Virus Isolation ◽  
Congenital Infection ◽  
Socioeconomic Background ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Low Socioeconomic ◽  
Cord Serum ◽  
Population Prevalence

In São Paulo, Brazil, between November 1980 and July 1982, 1614 newborns of middle socioeconomic background and 1156 newborns of low socioeconomic background were examined for the occurrence of congenital cytomegalovirus (CMV) infection by isolation of virus from urine samples or detection of specific anti-CMV IgM in umbilical cord serum tested by immunofluorescence. In the low socioeconomic population prevalence of CMV complement-fixing antibodies in mothers was 84.4%(151/179) and the incidence of congenital infection assessed by virus isolation 0.98% (5/508), as compared with 0.46% (3/648) in the group of newborns tested by detection of specific anti-CMV IgM in umbilical cord-serum. In middle socioeconomic level population prevalence of CMV complement-fixing antibodies in mothers was 66.5% (284/427) and the incidence of CMV congenital infection was 0.39% (2/518) in the group of newborns screened by virus isolation and 0.18% (2/1096) in the group tested by detection of specific anti-CMV IgM. In the present study none of the 12 congenitally infected newborns presented clinical apparent disease at birth.

Prenatal Diagnosis of 52 Pregnancies at Risk for Congenital Cytomegalovirus Infection

1993 ◽  
Vol 82 (4, Part 1) ◽  
pp. 481-486
Author(s):  
CATHERINE DONNER ◽  
CORINNE LIESNARD ◽  
JEAN CONTENT ◽  
ALAIN BUSINE ◽  
JULIETTE ADERCA ◽  
...  
Keyword(s):  
At Risk ◽  
Prenatal Diagnosis ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

Prenatal Diagnosis of 52 Pregnancies at Risk for Congenital Cytomegalovirus Infection

1993 ◽  
Vol 82 (4) ◽  
pp. 481-486 ◽  
Author(s):  
CATHERINE DONNER ◽  
CORINNE LIESNARD ◽  
JEAN CONTENT ◽  
ALAIN BUSINE ◽  
JULIETTE ADERCA ◽  
...  
Keyword(s):  
At Risk ◽  
Prenatal Diagnosis ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

scholarly journals Role of Maternal Serum Glycodelin as Predictor of Ectopic Pregnancy in First Trimester

2018 ◽  
Vol 7 (4) ◽  
pp. 467-470
Author(s):  
Wasan Wajdi Ibrahim ◽  
Afraa Mahjoob Al-Naddawi ◽  
Hayder A. Fawzi
Keyword(s):  
Ectopic Pregnancy ◽  
Predictive Value ◽  
First Trimester ◽  
Maternal Serum ◽  
Intrauterine Pregnancy ◽  
Receiver Operator Curve Analysis ◽  
Medical City ◽  
First Trimester Of Pregnancy ◽  
Control Study

Objectives: Assessment of glycodelin (GD) as a marker for unruptured ectopic pregnancy (EP) in the first trimester of pregnancy. Materials and Methods: This case-control study was conducted during June 2016 to May 2017 in the Obstetrics and Gynecological Department of Baghdad University at Baghdad teaching hospital/medical city complex. In this study, 100 pregnant women in their first trimester of pregnancy were included after clinical and ultrasonic findings. Results: Based on the results, GD levels in EP were significantly lower than those with normal intrauterine pregnancy (1.58 ± 1.18 vs. 30.1 ± 11.9). In addition, using receiver operator curve analysis, the cut-off GD level of 9.5 and less had acceptable validity results (100% sensitivity, 100% specificity, 95% positive predictive value, 100% negative predictive value, and accuracy 100%) to predict EP. Conclusions: In general, serum GD is considered as an excellent predictor of unruptured EP.

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