Two Cross-Protective Antigen Sites on Foot-and-Mouth Disease Virus Serotype O Structurally Revealed by Broadly Neutralizing Antibodies from Cattle

2021 ◽  
Vol 95 (21) ◽  
Author(s):  
Kun Li ◽  
Yong He ◽  
Li Wang ◽  
Pinghua Li ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Protective Antigen ◽  
Foot And Mouth Disease ◽  
Neutralizing Antibody ◽  
Mouth Disease ◽  
Antigenic Structure ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

FMDV is the causative agent of foot-and-mouth disease (FMD), which is one of the most contagious and economically devastating diseases of domestic animals. The antigenic structure of FMDV serotype O is rather complicated, especially for those sites that can elicit a cross-protective neutralizing antibody response.

scholarly journals Implication of Broadly Neutralizing Bovine Monoclonal Antibodies in the Development of an Enzyme-Linked Immunosorbent Assay for Detecting Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype O

2019 ◽  
Vol 57 (12) ◽  
Author(s):  
Yimei Cao ◽  
Kun Li ◽  
Sheng Wang ◽  
Yuanfang Fu ◽  
Pu Sun ◽  
...  
Keyword(s):  
Disease Virus ◽  
Neutralizing Antibodies ◽  
Foot And Mouth Disease ◽  
Neutralizing Antibody ◽  
Mouth Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serotype O ◽  
Fmdv Serotype ◽  
Mouth Disease Virus ◽  
Foot And Mouth

ABSTRACT Vaccination with inactivated vaccines is still the main measure to control foot-and-mouth disease (FMD) in areas where the disease is endemic, and the level of neutralizing antibody in vaccinated animals is directly related to their protection against virus challenge. Currently, neutralizing antibody is mainly detected using the virus neutralization test (VNT) based on cell culture, which is laborious and time-consuming and requires restrictive biocontainment facilities. In this study, two broadly neutralizing antibodies (bnAbs), E46 and F128, were successfully produced using techniques for the isolation of single B cells from peripheral blood mononuclear cells (PBMCs) from bovines sequentially immunized with three topotypes of foot-and-mouth disease virus (FMDV) serotype O. Based on these bnAbs, a blocking enzyme-linked immunosorbent assay (ELISA) for detecting neutralizing antibodies (NA-ELISA) against FMDV serotype O was developed. The specificity and sensitivity of the test were estimated to be 99.21% and 100%, respectively. A significant correlation (P < 0.01) was observed between the NA-ELISA titers and the VNT titers for all sera from vaccinated animals and for all tested strains, suggesting that the NA-ELISA could detect neutralizing antibodies against FMDV serotype O strains of wide antigenic and molecular diversity and could be used for the evaluation of protective immunity.

Antiviral potential of ivermectin against foot-and-mouth disease virus, serotype O, A and Asia-1

2021 ◽  
pp. 104914
Author(s):  
Zahra Naeem ◽  
Sohail Raza ◽  
Saba Afzal ◽  
Ali Ahmad Sheikh ◽  
Muhammad Muddassir Ali ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

scholarly journals Pandemic Strain of Foot-and-Mouth Disease Virus Serotype O

2005 ◽  
Vol 11 (12) ◽  
pp. 1887-1893 ◽  
Author(s):  
Nick J. Knowles ◽  
Alan R. Samuel ◽  
Paul R. Davies ◽  
Rebecca J. Midgley ◽  
Jean-François Valarcher
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Pandemic Strain ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Emergence of antigenic variants of Foot-and-Mouth Disease Virus serotype O in Ecuador and preliminary evaluation of a field strain as a vaccine candidate

Vaccine ◽  
2014 ◽  
Vol 32 (21) ◽  
pp. 2446-2451 ◽  
Author(s):  
Eduardo Maradei ◽  
Viviana Malirat ◽  
Claudia Perez Beascoechea ◽  
Ana María Espinoza ◽  
Sabrina Galdo Novo ◽  
...  
Keyword(s):  
Disease Virus ◽  
Vaccine Candidate ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Field Strain ◽  
Preliminary Evaluation ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Application of a recombinant capsid polyprotein (P1) expressed in a prokaryotic system to detect antibodies against foot-and-mouth disease virus serotype O

2015 ◽  
Vol 215-216 ◽  
pp. 45-51 ◽  
Author(s):  
Jitendra K. Biswal ◽  
Punam Bisht ◽  
Jajati K. Mohapatra ◽  
Rajeev Ranjan ◽  
Aniket Sanyal ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

Lack of susceptibility of the dromedary camel (Camelus dromedarius) to foot-and-mouth disease virus serotype O

2006 ◽  
Vol 158 (6) ◽  
pp. 201-203 ◽  
Author(s):  
U. Wernery ◽  
P. Nagy ◽  
C. M. Amaral-Doel ◽  
Z. Zhang ◽  
S. Alexandersen
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Camelus Dromedarius ◽  
Dromedary Camel ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth
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