The Probability of In Vivo Reactivation of Herpes Simplex Virus Type 1 Increases with the Number of Latently Infected Neurons in the Ganglia
1998 ◽
Vol 72
(8)
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pp. 6888-6892
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Keyword(s):
ABSTRACT The purpose of this study was to define the relationship between herpes simplex virus (HSV) latency and in vivo ganglionic reactivation. Groups of mice with numbers of latently infected neurons ranging from 1.9 to 24% were generated by varying the input titer of wild-type HSV type 1 strain 17syn+. Reactivation of the virus in mice from each group was induced by hyperthermic stress. The number of animals that exhibited virus reactivation was positively correlated with the number of latently infected neurons in the ganglia over the entire range examined (r = 0.9852, P< 0.0001 [Pearson correlation]).
2000 ◽
Vol 74
(13)
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pp. 5957-5967
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1998 ◽
Vol 72
(10)
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pp. 8257-8263
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Keyword(s):
1994 ◽
Vol 68
(3)
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pp. 1283-1292
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Keyword(s):
2008 ◽
Vol 14
(5)
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pp. 389-400
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Keyword(s):
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2004 ◽
Vol 78
(19)
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pp. 10470-10478
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Keyword(s):
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2002 ◽
Vol 76
(18)
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pp. 9232-9241
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Keyword(s):
1994 ◽
Vol 75
(9)
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pp. 2469-2474
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