Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants
1999 ◽
Vol 73
(1)
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pp. 362-367
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Keyword(s):
ABSTRACT Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.
Keyword(s):
1997 ◽
Vol 176
(4)
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pp. 904-912
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2008 ◽
Vol 85
(3)
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pp. 596-602
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1997 ◽
Vol 176
(3)
◽
pp. 798-800
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2003 ◽
Vol 23
(6)
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pp. 1007-1016
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2000 ◽
Vol 74
(22)
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pp. 10581-10588
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