Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50 Represses p53-Induced Transcriptional Activity and Apoptosis
2001 ◽
Vol 75
(13)
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pp. 6245-6248
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Keyword(s):
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here we show that ORF50 represses transcriptional activity of p53 and p53-induced apoptosis through interaction with CREB binding protein (CBP). This inhibitory effect of ORF50 on the transcriptional activity of p53 was relieved by the addition of CBP. ORF50 mutants, which are defective in interaction with CBP, lost the inhibitory effects on p53. Our data provide a framework for delineating the regulatory mechanisms used by KSHV to modulate cellular transcription and the cell cycle.
2001 ◽
Vol 277
(8)
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pp. 6438-6442
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2000 ◽
Vol 74
(8)
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pp. 3586-3597
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2000 ◽
Vol 74
(13)
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pp. 6207-6212
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2000 ◽
Vol 81
(4)
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pp. 1067-1071
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2005 ◽
Vol 79
(3)
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pp. 1397-1408
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1999 ◽
Vol 21
(1)
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pp. A13
2003 ◽
Vol 77
(6)
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pp. 3878-3881
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