scholarly journals Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes

2002 ◽  
Vol 76 (5) ◽  
pp. 2567-2572 ◽  
Author(s):  
A. C. M. Boon ◽  
G. de Mutsert ◽  
Y. M. F. Graus ◽  
R. A. M. Fouchier ◽  
K. Sintnicolaas ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Cytotoxic T Lymphocytes ◽  
T Lymphocyte ◽  
Influenza A ◽  
Sequence Variation ◽  
Cytotoxic T Lymphocyte ◽  
Chronological Order ◽  
Ctl Epitope ◽  
High Degree ◽  
Restricted Epitope

ABSTRACT Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

scholarly journals Influenza A Virus-Specific H-2dRestricted Cross-Reactive Cytotoxic T Lymphocyte Epitope(s) Detected in the Hemagglutinin HA2 Subunit of A/Udorn/72

Virology ◽  
1995 ◽  
Vol 214 (2) ◽  
pp. 445-452 ◽  
Author(s):  
KAMAL U. SAIKH ◽  
JOHN D. MARTIN ◽  
A.H. NISHIKAWA ◽  
SUSAN B. DILLON
Keyword(s):  
Influenza A Virus ◽  
T Lymphocyte ◽  
Influenza A ◽  
Cytotoxic T Lymphocyte

scholarly journals Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones

2007 ◽  
Vol 88 (2) ◽  
pp. 530-535 ◽  
Author(s):  
E. G. M. Berkhoff ◽  
M. M. Geelhoed-Mieras ◽  
R. A. M. Fouchier ◽  
A. D. M. E. Osterhaus ◽  
G. F. Rimmelzwaan
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
T Lymphocyte ◽  
Influenza A ◽  
Matrix Protein ◽  
Cytotoxic T Lymphocyte ◽  
H3n2 Virus ◽  
Human Virus ◽  
Ctl Epitopes ◽  
Cell Clones

The influenza A virus nucleoprotein (NP) and matrix protein are major targets for human virus-specific cytotoxic T-lymphocyte (CTL) responses. Most of the CTL epitopes that have been identified so far are conserved. However, sequence variation in CTL epitopes of the NP has recently been demonstrated to be associated with escape from virus-specific CTLs. To assess the extent of variation in CTL epitopes during influenza A virus evolution, 304 CTL clones derived from six study subjects were obtained with specificity for an influenza A/H3N2 virus isolated in 1981. Subsequently, the frequency of the CTL clones that failed to recognize a more recent influenza virus strain isolated in 2003 was determined. In four of six study subjects, CTLs were found to be specific for variable epitopes, accounting for 2.6 % of all CTL clones. For some of these CTL clones, the minimal epitope and the residues responsible for abrogation of T-cell recognition were identified.

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