Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression
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IFITs belong to a family of IFN-induced proteins that have broad antiviral functions, primarily studied with RNA viruses leaving a gap of knowledge on the effects of these proteins on DNA viruses. In this study we show that IFIT3, with its partner proteins IFIT1 and IFIT2, specifically restricts replication of human Ad, a DNA virus, by stimulating IFNβ production via the STING and MAVS pathways.
2004 ◽
Vol 124
(1)
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pp. 247-260
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1990 ◽
Vol 265
(35)
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pp. 21914-21921
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1994 ◽
Vol 24
(1-4)
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pp. 166-178
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