A yeast protein possesses the DNA-binding properties of the adenovirus major late transcription factor.
1989 ◽
Vol 9
(2)
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pp. 820-822
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Keyword(s):
The adenovirus major late transcription factor (MLTF), or upstream stimulatory factor, is a human promoter-specific transcription factor which recognizes the near-palindromic sequence GGCCACGTGACC (R. W. Carthew, L. A. Chodosh, and P. A. Sharp, Cell 43:439-448, 1985; L. A. Chodosh, R. W. Carthew, and P. A. Sharp, Mol. Cell. Biol. 6:4723-4733, 1986; M. Sawadogo and R. G. Roeder, Cell 43:165-175, 1985). We describe here a protein found in the yeast Saccharomyces cerevisiae which possesses DNA-binding properties that are virtually identical to those of human MLTF. These two proteins recognize the same DNA-binding site, make the same purine nucleotide contacts, and are affected in the same manner by mutations in the MLTF-binding site.
1988 ◽
Vol 263
(24)
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pp. 11994-12001
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1997 ◽
Vol 94
(7)
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pp. 2828-2832
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1993 ◽
Vol 13
(4)
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pp. 1983-1997
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Keyword(s):
2003 ◽
Vol 44
(1)
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pp. 161-166
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