scholarly journals Comparative Analysis of Pathobiochemical Changes in Major Depression and Post-Traumatic Stress Disorder

2021 ◽  
Vol 86 (6) ◽  
pp. 729-736
Author(s):  
Konstantin N. Stupin ◽  
Mikhail Y. Zenko ◽  
Elena A. Rybnikova

Abstract Comparative analysis of available literature data on the pathogenetic neuroendocrine mechanisms of depression and post-traumatic stress disorder (PTSD) is provided in this review to identify their common features and differences. We discuss the multidirectional modifications of the activity of cortical and subcortical structures of the brain, levels of neurotransmitters and their receptors, and functions of the hypothalamic-pituitary-adrenocortical axis in depression and PTSD. The analysis shows that these disorders are examples of opposite failures in the system of adaptive stress response of the body to stressful psychotraumatic events. On this basis, it is concluded that the currently widespread use of similar approaches to treat these disorders is not justified, despite the significant similarity of their anxiety-depressive symptoms; development of differential therapeutic strategies is required.

Author(s):  
Richard Biehl

In this chapter, the author talks about his teaching of somatic yoga for relief of trauma, supporting this with current research on post-traumatic stress disorder (PTSD) and including parts of his own story with PTSD. He has been practicing yoga since 1992 and expands his bodily pursuits through an active intellectual life. Here he offers an in-depth discussion based on research and his personal experience of the role of body consciousness in trauma and traumatic illnesses. He explores various ways to develop conscious embodiment in focused, restorative, and ultimately safe ways through engagement of the wisdom of the natural body and thereby to recover and potentially heal from traumatic stress and illness. In conclusion, he emphasizes that simple somatic methods anchored on breath and movement with mindfulness make it possible to heal traumatic illness and can provide immediate relief to experiences of both acute and chronic distress.


Author(s):  
F. Susan Zengerle

Studies published in the last few years have suggested that the current practice in hospital obstetric units of encouraging parents to spend time with, hold, and even care for their stillborn fetus or baby may be deleterious to them. Rather than helping to allay grieving and successfully bring mourning to closure, mothers who had increasing levels of contact with the body of their stillborn baby were incrementally more likely to suffer depression and symptoms of post-traumatic stress disorder in their next pregnancy and to have difficulty with attachment to their next child. These findings parallel observations from meta-analyses that question the efficacy of single-session debriefing (Critical Incident Stress Debriefing) after psychological trauma in preventing the later emergence of symptoms of post-traumatic stress disorder. Although not conclusive, these initial studies support the urgent need for further research to allow evidence-based pastoral care for those whose pregnancies end in stillbirth and loss. Given this much uncertainty about the risks posed by contact with her stillborn baby, mothers who do not chose to see their dead infants should not be persuaded to do so on the grounds of beneficence.


2007 ◽  
Vol 38 (4) ◽  
pp. 467-480 ◽  
Author(s):  
Y. Neria ◽  
A. Nandi ◽  
S. Galea

BackgroundDisasters are traumatic events that may result in a wide range of mental and physical health consequences. Post-traumatic stress disorder (PTSD) is probably the most commonly studied post-disaster psychiatric disorder. This review aimed to systematically assess the evidence about PTSD following exposure to disasters.MethodA systematic search was performed. Eligible studies for this review included reports based on the DSM criteria of PTSD symptoms. The time-frame for inclusion of reports in this review is from 1980 (when PTSD was first introduced in DSM-III) and February 2007 when the literature search for this examination was terminated.ResultsWe identified 284 reports of PTSD following disasters published in peer-reviewed journals since 1980. We categorized them according to the following classification: (1) human-made disasters (n=90), (2) technological disasters (n=65), and (3) natural disasters (n=116). Since some studies reported on findings from mixed samples (e.g. survivors of flooding and chemical contamination) we grouped these studies together (n=13).ConclusionsThe body of research conducted after disasters in the past three decades suggests that the burden of PTSD among persons exposed to disasters is substantial. Post-disaster PTSD is associated with a range of correlates including sociodemographic and background factors, event exposure characteristics, social support factors and personality traits. Relatively few studies have employed longitudinal assessments enabling documentation of the course of PTSD. Methodological limitations and future directions for research in this field are discussed.


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