Zinc finger protein 521 suppresses osteogenic differentiation of rat mesenchymal stem cells by inhibiting the Wnt/beta-catenin signaling pathway

2017 ◽  
Vol 51 (3) ◽  
pp. 408-415 ◽  
Author(s):  
X.-T. Xie ◽  
X.-L. Zhan ◽  
Z.-H. Hu
2019 ◽  
Vol 31 (8) ◽  
pp. 1315 ◽  
Author(s):  
Daguia Zambe John Clotaire ◽  
Yudong Wei ◽  
Xiuwei Yu ◽  
Tamgue Ousman ◽  
Jinlian Hua

Promyelocytic leukaemia zinc finger (Plzf), also known as zinc finger and BTB domain containing 16 (ZBTB16) or zinc-finger protein 145 (ZFP145), is a critical zinc finger protein of male germline stem cells (mGSCs). Multiple lines of evidence indicate that Plzf has a central role in the development, differentiation and maintenance of many stem cells, including mGSCs, and Plzf has been validated as an essential transcription factor for mammalian testis development and spermatogenesis. This review summarises current literature focusing on the significance of Plzf in maintaining and regulating self-renewal and differentiation of mGSCs, especially goat mGSCs. The review summarises evidence of the specificity of Plzf expression in germ cell development stage, the known functions of Plzf and the microRNA-mediated mechanisms that control Plzf expression in mGSCs.


Bone ◽  
2009 ◽  
Vol 45 (2) ◽  
pp. 367-376 ◽  
Author(s):  
Katrin Hess ◽  
Alexey Ushmorov ◽  
Jörg Fiedler ◽  
Rolf E. Brenner ◽  
Thomas Wirth

Sign in / Sign up

Export Citation Format

Share Document