Design and Synthesis of Novel 1a,3,4-Oxadiazole Derivatives as Cytotoxic Agents: A Combined Experimental and Docking Study

Russian Journal of Organic Chemistry ◽

10.1134/s1070428020050280 ◽

2020 ◽

Vol 56 (5) ◽

pp. 924-934

Author(s):

P. Perla ◽

N. Seelam ◽

R. Bera

Keyword(s):

Docking Study ◽

Cytotoxic Agents ◽

Design And Synthesis ◽

Oxadiazole Derivatives

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Design and synthesis of novel 1, 2,4 Oxadiazole derivatives as potent anti-cancer agents

Advances in Pharmacoepidemiology & Drug Safety ◽

10.4172/2167-1052-c1-003 ◽

2017 ◽

Vol 06 (03) ◽

Author(s):

Ankur Vaidya

Keyword(s):

Design And Synthesis ◽

Anti Cancer ◽

Oxadiazole Derivatives

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Design and synthesis of novel camptothecin/5-fluorouracil conjugates as cytotoxic agents

Natural Product Research ◽

10.1080/14786411003792181 ◽

2011 ◽

Vol 25 (19) ◽

pp. 1817-1826 ◽

Author(s):

Ying-Qian Liu ◽

Wei Dai ◽

Liu Yang ◽

Hong-Yu Li

Keyword(s):

Cytotoxic Agents ◽

Design And Synthesis

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Synthesis, spectroscopic analyses, chemical reactivity and molecular docking study and anti-tubercular activity of pyrazine and condensed oxadiazole derivatives

Journal of Molecular Structure ◽

10.1016/j.molstruc.2018.03.085 ◽

2018 ◽

Vol 1164 ◽

pp. 459-469 ◽

Author(s):

Abdul-Malek S. Al-Tamimi ◽

Y. Sheena Mary ◽

Pankaj B. Miniyar ◽

Lamya H. Al-Wahaibi ◽

Ali A. El-Emam ◽

...

Keyword(s):

Molecular Docking ◽

Chemical Reactivity ◽

Docking Study ◽

Molecular Docking Study ◽

Spectroscopic Analyses ◽

Oxadiazole Derivatives

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Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112874 ◽

2021 ◽

Vol 209 ◽

pp. 112874

Author(s):

Min Wang ◽

Tongtong Liu ◽

Shiming Chen ◽

Mingfei Wu ◽

Jianfei Han ◽

...

Keyword(s):

Design And Synthesis ◽

Oxadiazole Derivatives ◽

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Abstract 1929: Antifolates as folate receptor targeting ligands: Design and synthesis of their conjugates with cytotoxic agents

10.1158/1538-7445.am2012-1929 ◽

2012 ◽

Author(s):

Iontcho Vlahov ◽

Fei You ◽

Ryan Dorton ◽

Elaine Westrick ◽

Joseph Reddy ◽

...

Keyword(s):

Folate Receptor ◽

Cytotoxic Agents ◽

Receptor Targeting ◽

Design And Synthesis ◽

Folate Receptor Targeting

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Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.06.060 ◽

2014 ◽

Vol 24 (16) ◽

pp. 3850-3853 ◽

Author(s):

Xiao-Bo Zhao ◽

Masuo Goto ◽

Zi-Long Song ◽

Susan L. Morris-Natschke ◽

Yu Zhao ◽

...

Keyword(s):

Cytotoxic Agents ◽

Design And Synthesis

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Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2016.02.043 ◽

2016 ◽

Vol 26 (7) ◽

pp. 1776-1783 ◽

Author(s):

N.C. Desai ◽

Hardik Somani ◽

Amit Trivedi ◽

Kandarp Bhatt ◽

Laxman Nawale ◽

...

Keyword(s):

Molecular Docking ◽

Docking Study ◽

Biological Evaluation ◽

Antitubercular Agents ◽

Molecular Docking Study ◽

Oxadiazole Derivatives

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Synthesis, characterization and interaction studies of 1,3,4-oxadiazole derivatives of fatty acid with human serum albumin (HSA): A combined multi-spectroscopic and molecular docking study

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.06.012 ◽

2016 ◽

Vol 122 ◽

pp. 72-78 ◽

Author(s):

Khairujjaman Laskar ◽

Parvez Alam ◽

Rizwan Hasan Khan ◽

Abdul Rauf

Keyword(s):

Molecular Docking ◽

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Docking Study ◽

Molecular Docking Study ◽

Interaction Studies ◽

Oxadiazole Derivatives ◽

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Synthesis, molecular docking study and in vitro thymidine phosphorylase inhibitory potential of oxadiazole derivatives

Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.02.020 ◽

2018 ◽

Vol 78 ◽

pp. 58-67 ◽

Author(s):

Hayat Ullah ◽

Fazal Rahim ◽

Muhammad Taha ◽

Imad Uddin ◽

Abdul Wadood ◽

...

Keyword(s):

Molecular Docking ◽

Thymidine Phosphorylase ◽

Docking Study ◽

Molecular Docking Study ◽

Oxadiazole Derivatives ◽

Inhibitory Potential

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Design and Synthesis of 4-O-Podophyllotoxin Sulfamate Derivatives as Potential Cytotoxic Agents

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/6672807 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Ammar Bader ◽

Majdi M. Bkhaitan ◽

Ashraf N. Abdalla ◽

Qasem M. A. Abdallah ◽

Hamed I. Ali ◽

...

Keyword(s):

Sulfonyl Chloride ◽

Colon Adenocarcinoma ◽

Biological Evaluation ◽

Cytotoxic Agents ◽

Normal Lung ◽

Dependent Manner ◽

Design And Synthesis ◽

Apoptotic Effect ◽

4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. The prepared compounds were afforded by reacting O-sulfonyl chloride podophyllotoxin with ammonia or aminoaryl/heteroaryl motif. Biological evaluation was performed in human breast cancer (MCF7), ovarian cancer (A2780), colon adenocarcinoma (HT29), and normal lung fibroblast (MRC5) cell lines. Compound 3 exhibited potent inhibitory activity and good selectivity margin. Compounds 2, 3, and 7 exerted apoptotic effect in MCF7 cells in a dose-dependent manner. The cytotoxicity of the verified compounds was inferior to that of podophyllotoxin.

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