Microemulsions and Lyotropic Liquid Crystals of Lecithin as Systems for Transdermal Drug Delivery

Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix. The intricate nanostructures of the cubic phase and hexagonal phase have been shown to provide diffusion controlled release of active pharmaceutical ingredients with a wide range of molecular weights and polarities. In addition, the biodegradable and biocompatible nature of lipids demonstrates the minimum toxicity and thus they are used for various routes of administration. Therefore, the research on lipid-based lyotropic liquid crystalline phases has attracted a lot of attention in recent years. This review will provide an overview of the lipids used to prepare cubic phase and hexagonal phase at physiological temperature, as well as the influencing factors on the phase transition of liquid crystals. In particular, the most current research progresses on cubic and hexagonal phases as drug delivery systems will be discussed.

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Recent Developments in Lyotropic Liquid Crystals as Drug Delivery Vehicles

Self-Assembled Supramolecular Architectures ◽

10.1002/9781118336632.ch8 ◽

2012 ◽

pp. 219-256 ◽

Cited By ~ 1

Author(s):

Dima Libster ◽

Abraham Aserin ◽

Nissim Garti

Keyword(s):

Drug Delivery ◽

Liquid Crystals ◽

Lyotropic Liquid Crystals ◽

Drug Delivery Vehicles ◽

Recent Developments ◽

Delivery Vehicles

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A Review On Lyotropic Liquid Crystals And Its Potential Applications

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681211666210204114532 ◽

2021 ◽

Vol 11 ◽

Author(s):

Hitesh Kumar ◽

Aishwarya Sureshkumar ◽

Nihal Badduri ◽

Vikas Jain

Keyword(s):

Drug Delivery ◽

Liquid Crystals ◽

Drug Delivery Systems ◽

Liquid Crystalline ◽

Structural Features ◽

Delivery Systems ◽

Lyotropic Liquid Crystals ◽

Liquid Phases ◽

Potential Applications ◽

Novel Drug

Backgraound: Novel drug delivery systems have always been of immense interest for research. Majority of the drugs suffers from solubity related constraints. Lipid based drug delivery systems provide a promising approach to address this issue.Amogst various approaches, liquid crystalline systems offers distinct advantages over other available options. It maintains the phase stablility between solid and liquid phases. Backgraound: :Novel drug delivery systems have always been of immense interest for research. Majority of the drugs suffers from solubity related constraints. Lipid based drug delivery systems provide a promising approach to address this issue.Amogst various approaches, liquid crystalline systems offers distinct advantages over other available options. It maintains the phase stablility between solid and liquid phases. Objective: Lyotropic Liquid Crystals (LLCs) have highly ordered internal structure forming capabilities thereby assisting the controlled release of a therapeutic agent of varying sizes and polarities. Methods: The present article covers the structural features of dispersed mesophases (cubosomes and hexosomes), components used to prepare various mesophases, method of preparation, characterization techniques and potential applications. Results: LLCsoffers a distinct choice for delivering hydrophobic as well as hydrophilic drug. They are also suitable for the delivery of macromolecules such as peptide and protiens through various routes of administration.Lyotropic liquid crystals are extremely versatile drug delivery systems that can be used for delivering drugs across topical, oral, buccal, pulmonary and intravenous routes. Their use in the delivery of tough to deliver drugs, hormones, peptides, biomolecules and vaccines is particularly important. Conclusion: This review discussed the composition, methods of preparation and characterization of LLCs. The LLCs offer promsing delivery choice for the drugs with lower solubility and higher toxicity.

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