Electrochemical and biological oxidation of 1,4-dihydropyridine derivatives

1981 ◽  
Vol 46 (5) ◽  
pp. 1141-1147 ◽  
Author(s):  
Antonín Kurfürst ◽  
Jiří Ludvík ◽  
Pavel Rauch ◽  
Miroslav Marek
Keyword(s):  
Electrochemical Reduction ◽  
Nitro Group ◽  
Electrochemical Oxidation ◽  
Respiratory Chain ◽  
Enzyme System ◽  
Biological Oxidation ◽  
Common Trends ◽  
Cyclic Voltametry ◽  
Dihydropyridine Derivatives

Electrochemical oxidation of 1,4-dihydropyridines I-XII and electrochemical reduction of the nitro group of 4-(2-nitrophenyl)-1,4-dihydropyridines III, VI, IX and XII was studied using cyclic voltametry. When comparing the electrochemical and the biological oxidation of 3,5-dimethoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine (IX, Nifedipine) and related 1,4-dihydropyridines it was found that in spite of certain common trends the oxidation of these compounds (I-XII) in the organism cannot be predicted unambiguously. Of the substances tested compounds IX and XI (3,5-diethoxycarbonyl-4-phenyl-2,6-dimethyl-1,4-dihydropyridine) were the least oxidizable by the respiratory chain, and at the same time they did not inhibit this enzyme system. In addition to this, compound IX was the least oxidizable by the microsomal system.

Elektrochemische Eigenschaften von Dihydropyridin-und Pyridinderivaten / Electrochemical Properties of Pyridine and Dihydropyridine Derivatives

1981 ◽  
Vol 36 (3) ◽  
pp. 386-390 ◽  
Author(s):  
G. Abou-Elenien ◽  
J. Rieser ◽  
N. Ismail ◽  
K. Wallenfels
Keyword(s):  
Electrochemical Properties ◽  
Electrochemical Oxidation ◽  
Supporting Electrolyte ◽  
Aqueous Solvent ◽  
Dihydropyridine Derivatives

AbstractThe electrochemical oxidation and reduction properties of different dihydropyridines and pyridines have been investigated in non aqueous solvent as benzonitrile and aceto-nitrile with tetra-n-butylammonium perchlorate as supporting electrolyte at platinium electrodes using DC-voltametry, cycl. voltametry and coulometry. Possible redox-mechanisms are discussed.

Electrochemical oxidation of N-substituted 1,4- and 1,2-dihydropyridine derivatives

1987 ◽  
Vol 226 (1-2) ◽  
pp. 103-116 ◽  
Author(s):  
J. Stradins ◽  
J. Ogle ◽  
V. Kadysh ◽  
L. Baumane ◽  
R. Gavars ◽  
...  
Keyword(s):  
Electrochemical Oxidation ◽  
Dihydropyridine Derivatives

scholarly journals Liver Mitochondrial Enzyme System In The Dynamics Of Experimental Leukemia

2012 ◽  
Vol 4 ◽  
Author(s):  
Gulmira Kasymova ◽  
Ulugbek Zaribbaev
Keyword(s):  
Lipid Peroxidation ◽  
Respiratory Chain ◽  
Enzyme System ◽  
Mitochondrial Enzymes ◽  
Mitochondrial Enzyme ◽  
Antioxidant Protection ◽  
Complex Iv ◽  
Experimental Leukemia

In rats with leukemia activity of liver mitochondrial enzymes are decreased at 6 months. Later, we noted compensatory activation of complexes II and III of the respiratory chain and transition to decompensation stage by final deadline. The activity of complex IV of the respiratory chain remains high. These changes result from increased lipid peroxidation and decreased activity of antioxidant protection enzymes.

Remarkable increase in luminol electrochemiluminescence by sequential electroreduction and electrooxidation

2014 ◽  
Vol 50 (93) ◽  
pp. 14662-14665 ◽  
Author(s):  
Xiaoyun Liu ◽  
Wenjing Qi ◽  
Wenyue Gao ◽  
Zhongyuan Liu ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Electrochemical Reduction ◽  
Electrochemical Oxidation ◽  
Linear Sweep Voltammetry ◽  
Sensitive Detection ◽  
Linear Sweep ◽  
Remarkable Increase

Luminol electrochemiluminescence is dramatically increased by about five hundred times by coupling electrochemical reduction and electrochemical oxidation using simple linear sweep voltammetry, enabling sensitive detection.

Coulometry in resonator cavity of EPR spectrometer: Electrochemical oxidation of carbazole methyl derivatives

1981 ◽  
Vol 46 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Pavel Kubáček
Keyword(s):  
Electrochemical Reduction ◽  
Electrochemical Oxidation ◽  
Electrode Surface ◽  
Cation Radical ◽  
Radical Product ◽  
Spin Concentration ◽  
Resonator Cavity ◽  
Methyl Derivatives ◽  
Simultaneous Measuring ◽  
Radical Character

Electrochemical reduction of carbazole, 3-methyl- and 3,9-dimethylcarbazole in acetonitrile leads to the formation of a layer of conductive, insoluble products on the electrode surface of a partially radical character. This phenomenon was studied by coulometry in the resonator cavity of an EPR spectrometer with simultaneous measuring of the spin concentration. With carbazole and 3-methylcarbazole, the radical particles are formed with a yield of about 2% with respect to the current passed, whereas with 3,9-dimethylcarbazole this yield is by an order or magnitude lower. The radical product adsorbed on the electrode is probably a sparingly soluble perchlorate of the cation radical of 3,3'- or 6,6'-bicarbazole. 3,6,9-Trimethylcarbazole gives on oxidation a relatively stable primary cation radical. Electrochemical oxidation of 9-methyl- and 3,6-dimethylcarbazole does not lead to radical products.

Substituent effect in electrochemical and ferricyanide oxidations of para-substituted 1-benzyl-3-carbamoyl-1,4-dihydropyridines

1983 ◽  
Vol 48 (5) ◽  
pp. 1408-1421 ◽  
Author(s):  
Františka Pavlíková-Raclová ◽  
Josef Kuthan
Keyword(s):  
Electrochemical Oxidation ◽  
Rate Constants ◽  
Substituent Effect ◽  
Potassium Ferricyanide ◽  
Rotating Disc Electrode ◽  
Disc Electrode ◽  
Rotating Disc ◽  
Half Wave ◽  
Substituted 1 ◽  
Dihydropyridine Derivatives

Half-wave potentials E1/2 of electrochemical oxidation of the title 1,4-dihydropyridine derivatives with the substituents N(CH3)2, OCH3, CH3, H, F, Cl, COOCH3, and CN have been measured on platinum rotating disc electrode in aqueous and anhydrous dimethylformamide, and apparent rate constants k2 of their oxidation with potassium ferricyanide have been measured in water at 298 K. The two quantities (E1/2 and k2) have been correlated both mutually and with empirical σp constants of the substituents. The found correlation relations have been discussed with respect to mechanism of the two transformations investigated.

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