(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)methylamine, (4-methoxy-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-methylamine and derivatives; Synthesis and pharmacological screening
1982 ◽
Vol 47
(3)
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pp. 984-993
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Keyword(s):
Using the Curtius reaction, the acids VIa and VIv were transformed to the carbamates IVa and IVb which afforded by alkaline hydrolysis the primary amines Ia and Ib. The N-methyl derivatives IIab were obtained by reduction of the carbamates IVa with lithium aluminium hydride. The N,N-dimethyl derivatives IIIab resulted by methylation of the primary amines Iab with formaldehyde and formic acid. The synthesis of the acid VIb was carried out from phthalide and 2-methoxythiophenol in seven steps. The amines Iab-IIIab showed clear thymoleptic properties in the test of reserpine ptosis in mice and by inhibition of the perphenazine catalepsy in rats. The acid VIb has antiinflammatory activity.
1981 ◽
Vol 46
(8)
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pp. 1800-1807
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1985 ◽
Vol 50
(8)
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pp. 1888-1898
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1983 ◽
Vol 48
(2)
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pp. 642-648
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1990 ◽
Vol 55
(4)
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pp. 1077-1098
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1990 ◽
Vol 55
(9)
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pp. 2282-2303
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1981 ◽
Vol 46
(1)
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pp. 148-160
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Keyword(s):
1983 ◽
Vol 48
(1)
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pp. 156-162
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1986 ◽
Vol 51
(7)
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pp. 1494-1502
1989 ◽
Vol 54
(7)
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pp. 1979-1994
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