Potential antidepressants: 4-(Thioaryloxy)piperidines

1989 ◽  
Vol 54 (8) ◽  
pp. 2240-2247 ◽  
Author(s):  
Karel Šindelář ◽  
Marta Hrubantová ◽  
Emil Svátek ◽  
Oluše Matoušová ◽  
Jiřina Metyšová ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Sodium Hydride ◽  
Antidepressant Activity ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions ◽  
Behavioural Tests

Nucleophilic substitution reactions of a series of thio-substituted fluoroarenes with 1-methyl-4-piperidinol, 1-benzyl-4-piperidinol, and 1-methyl-4-phenyl-4-piperidinol in the presence of sodium hydride in dimethylformamide gave the title compounds V-XI and XIII. The salts of these bases were pharmacologically tested and salts of compounds V, XI, and XIII showed in behavioural tests properties which are indicative of antidepressant activity.

scholarly journals Leaving Group Ability in Nucleophilic Aromatic Amination by Sodium Hydride–Lithium Iodide Composite

Synthesis ◽  
2019 ◽  
Vol 52 (03) ◽  
pp. 393-398
Author(s):  
Jia Hao Pang ◽  
Derek Yiren Ong ◽  
Kohei Watanabe ◽  
Ryo Takita ◽  
Shunsuke Chiba
Keyword(s):  
Nucleophilic Substitution ◽  
Methoxy Group ◽  
Sodium Hydride ◽  
Lithium Iodide ◽  
Substitution Reactions ◽  
Computational Approaches ◽  
Nucleophilic Substitution Reactions ◽  
Leaving Group ◽  
Leaving Group Ability

The methoxy group is generally considered as a poor leaving group for nucleophilic substitution reactions. This work verified the superior ability of the methoxy group in nucleophilic amination of arenes mediated by the sodium hydride and lithium iodide through experimental and computational approaches.

The unexpected reactivity of 9-iodo-nido-carborane: from nucleophilic substitution reactions to the synthesis of tricobalt tris(dicarbollide) Na[4,4′,4′′-(MeOCH2CH2O)3-3,3′,3′′-Co3(μ3-O)(μ3-S)(1,2-C2B9H10)3]

2021 ◽  
Vol 50 (7) ◽  
pp. 2671-2688
Author(s):  
Marina Yu. Stogniy ◽  
Sergey A. Anufriev ◽  
Akim V. Shmal'ko ◽  
Sergey M. Antropov ◽  
Aleksei A. Anisimov ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions

An unusual reactivity of 9-iodo-nido-carborane [9-I-7,8-C2B9H11]− towards nucleophiles under strong basic conditions was revealed.

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