Structural modification and new methods for preparation of ofloxacin analogs

1991 ◽  
Vol 56 (9) ◽  
pp. 1937-1943 ◽  
Author(s):  
Stanislav Rádl ◽  
Lenka Kovářová ◽  
Jaroslav Moural ◽  
Radoslava Bendová
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification ◽  
Sodium Hydrogen Carbonate ◽  
Methyl Derivative ◽  
New Methods ◽  
Sodium Hydrogen ◽  
Hydrogen Carbonate ◽  
Alkaline Conditions ◽  
Methylene Derivative

Reaction of ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate IIb with 2-amino-1-propanol provided corresponding compound IIIb which under alkaline conditions underwent an aromatic denitrocyclization reaction which after alkaline saponification provided 10-chloro-9-fluoro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Vd. Treatment of 8-hydroxyquinolone VIII with 3-bromopropyne in the presence of sodium hydrogen carbonate provided methylene derivative VIIb which was saponified into a appropriate acid VIIc. Compound VIIb treated with N-methylpiperazine and then saponified yielded VIIa. Hydrogenation of 3-methylene derivative VIIb provided 3-methyl derivative Va.

scholarly journals Experiments towards the Synthesis of the Ergot Alkaloids and Related Structures. Part 7.1 Novel Syntheses of some 4-Acyl-2,3,4,4a,5,6-hexahydrobenzo[f]quinolin-2-ones

1999 ◽  
Vol 23 (2) ◽  
pp. 94-95
Author(s):  
Mark A. E. Bowman ◽  
Ralph E. Bowman
Keyword(s):  
Sodium Hydrogen Carbonate ◽  
Ergot Alkaloids ◽  
Aqueous Sodium ◽  
Sodium Hydrogen ◽  
Hydrogen Carbonate ◽  
Aqueous Sodium Hydrogen Carbonate

Reaction of the N-formyl enol-lactone 4 and the corresponding N-acetyl 10 and N-methoxycarbonyl 11 derivatives with bis(trimethylsilyl)potassiomalonate in THF at 60°C followed by treatment with aqueous sodium hydrogen carbonate and cyclisation as above, yielded the 4-formyl-, 4-acetyl- and 4-methoxycarbonyl-tricyclic ketones 7, 13 and 14 in yields of 31, 35 and 36%, respectively.

Effect of Different Solutions on Hydrothermal Treatment of β-Tricalcium Phosphate Scaffold

2017 ◽  
Vol 264 ◽  
pp. 66-69
Author(s):  
Fadilah Darus ◽  
Mariatti Jaafar
Keyword(s):  
Hydrothermal Treatment ◽  
Sodium Hydrogen Carbonate ◽  
Surface Characteristics ◽  
Carbonate Apatite ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
X Ray ◽  
Sodium Hydrogen ◽  
Hydrogen Carbonate ◽  
Before And After

Carbonate apatite would be ideal for bone substitute due to its composition of 4-8% carbonate similar to bone mineral. The purpose of the present study was to produce carbonate apatite scaffold by using hydrothermal treatment of β-TCP scaffold as a precursor. The effect of different solutions on hydrothermal treatment was studied. The microstructure of scaffold before and after hydrothermal were characterized by scanning electron microscopy (SEM). It is observed that surface characteristics are governed by the types of immersion solution. The typical smooth surface of the β-TCP scaffold was observed before hydrothermal. Different morphology was observed after hydrothermal in different solutions. X-Ray Diffraction (XRD) pattern indicates that the peak of apatite with low intensities present after hydrothermal treatment in sodium hydrogen carbonate solution.

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