Changes of AT1 receptor expression in rat adipose tissue with respect to adiposity

2005 ◽  
Author(s):  
Katarína Tybitanclová ◽  
Štefan Zorad
Keyword(s):  
Adipose Tissue ◽  
At1 Receptor ◽  
Receptor Expression ◽  
Rat Adipose Tissue

Fasting inhibits natriuretic peptides clearance receptor expression in rat adipose tissue

1995 ◽  
Vol 13 (11) ◽  
pp. 1241-1246 ◽  
Author(s):  
Riccardo Sarzani ◽  
Vittoria M. Paci ◽  
Cristina M. Zingaretti ◽  
Claudia Pierleoni ◽  
Saverio Cinti ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Natriuretic Peptides ◽  
Receptor Expression ◽  
Clearance Receptor ◽  
Rat Adipose Tissue

scholarly journals Down-regulation of β3-adrenergic receptor expression in rat adipose tissue during the fasted/fed transition: evidence for a role of insulin

1997 ◽  
Vol 323 (2) ◽  
pp. 359-364 ◽  
Author(s):  
Khadija El HADRI ◽  
Christine CHARON ◽  
Jacques PAIRAULT ◽  
Sylvie HAUGUEL-DE MOUZON ◽  
Annie QUIGNARD-BOULANGÉ ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Adrenergic Receptor ◽  
Plasma Insulin ◽  
Present Report ◽  
Receptor Expression ◽  
Mrna Levels ◽  
Insulin Levels ◽  
Brown Adipose ◽  
Plasma Insulin Levels ◽  
Rat Adipose Tissue

The β3-adrenergic receptor (β3-AR) exerts a central role in the transduction of catecholamine effects in white and brown adipose tissue (WAT and BAT). A recent report has documented that insulin strongly down-regulates β3-AR expression and catecholamine responsiveness in 3T3-F442A adipocytes [Fève, El Hadri, Quignard-Boulangé and Pairault (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 5677–5681]. In the present report we show that the rise in plasma insulin levels elicited by the fasted/fed transition is associated with a reduction in β3-AR mRNA levels and β-adrenergic responsiveness in WAT and BAT. β3-AR transcripts are also decreased in adipose tissue from animals subjected for 6 h to euglycaemic hyperinsulinaemic glucose clamps. Moreover, insulin acts directly on cultured rat white and brown adipocytes to decrease β3-AR gene expression and adenylate cyclase activity in response to β3-AR-selective agonists. These results suggest that there is a close relationship between food intake, plasma insulin levels and β3-AR expression.

Depot differences in steroid receptor expression in adipose tissue: possible role of the local steroid milieu

2005 ◽  
Vol 288 (1) ◽  
pp. E200-E207 ◽  
Author(s):  
S. Rodriguez-Cuenca ◽  
M. Monjo ◽  
A. M. Proenza ◽  
P. Roca
Keyword(s):  
Adipose Tissue ◽  
Sex Hormones ◽  
Steroid Receptor ◽  
Receptor Expression ◽  
Mrna Levels ◽  
Adipose Tissues ◽  
Tissue Levels ◽  
Adipose Tissue Depots ◽  
Rat Adipose Tissue

Sex hormones play an important role in adipose tissue metabolism by activating specific receptors that alter several steps of the lipolytic and lipogenic signal cascade in depot- and sex-dependent manners. However, studies focusing on steroid receptor status in adipose tissue are scarce. In the present study, we analyzed steroid content [testosterone (T), 17β-estradiol (17β-E2), and progesterone (P4)] and steroid receptor mRNA levels in different rat adipose tissue depots. As expected, T levels were higher in males than in females ( P = 0.031), whereas the reverse trend was observed for P4 ( P < 0.001). It is noteworthy that 17β-E2 adipose tissue levels were higher in inguinal than in the rest of adipose tissues for both sexes, where no sex differences in 17β-E2 tissue levels were noted ( P = 0.010 for retroperitoneal, P = 0.005 for gonadal, P = 0.018 for mesenteric). Regarding steroid receptor levels, androgen (AR) and estrogen receptor (ER)α and ERβ densities were more clearly dependent on adipose depot location than on sex, with visceral depots showing overall higher mRNA densities than their subcutaneous counterparts. Besides, expression of ERα predominated over ERβ expression, and progesterone receptor (PR-B form and PR-A+B form) mRNAs were identically expressed regardless of anatomic depot and sex. In vitro studies in 3T3-L1 cells showed that 17β-E2 increased ERα ( P = 0.001) and AR expression ( P = 0.001), indicating that estrogen can alter estrogenic and androgenic signaling in adipose tissue. The results highlighted in this study demonstrate important depot-dependent differences in the sensitivity of adipose tissues to sex hormones between visceral and subcutaneous depots that could be related to metabolic situations observed in response to sex hormones.

scholarly journals Cellular and vascular development in immature rat adipose tissue.

1983 ◽  
Vol 24 (5) ◽  
pp. 522-532
Author(s):  
G J Hausman ◽  
R L Richardson
Keyword(s):  
Adipose Tissue ◽  
Vascular Development ◽  
Immature Rat ◽  
Rat Adipose Tissue

scholarly journals Effects of age and cell size on rat adipose tissue metabolism.

1975 ◽  
Vol 16 (6) ◽  
pp. 461-464 ◽  
Author(s):  
G Holm ◽  
B Jacobsson ◽  
P Björntorp ◽  
U Smith
Keyword(s):  
Adipose Tissue ◽  
Cell Size ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Rat Adipose Tissue
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