SAT0025 The Association Serum Interleukin 17 and Interleukin 23 Levels with Clinical and Radiological Parameters in Rheumatoid Arthritis Patients

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A588.1-A588
Author(s):  
U. Ucar ◽  
M. T. Duruoz ◽  
Y. Guvenc ◽  
S. Orguc
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 17 ◽  
Radiological Parameters ◽  
Interleukin 23

Levels of Interleukin 17 , Interleukin 23 and Interleukin 27 in Rheumatoid Arthritis and Osteoarthritis in Egyptian Patients

2013 ◽  
Vol 42 (4) ◽  
pp. 629-642 ◽  
Author(s):  
Ashraf Ismail Mustafa Khalifa ◽  
Hanan Abd Elmawgood Atia ◽  
Sara Saad
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 17 ◽  
Interleukin 27 ◽  
Egyptian Patients ◽  
Interleukin 23

scholarly journals Proteomic characterisations of ulcerative colitis endoscopic biopsies associate with clinically relevant histological measurements of disease severity

2021 ◽  
pp. jclinpath-2021-207718
Author(s):  
Aaron M Gruver ◽  
Matt D Westfall ◽  
Bradley L Ackermann ◽  
Salisha Hill ◽  
Ryan D Morrison ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Accuracy Assessment ◽  
Interleukin 2 ◽  
Proteome Analysis ◽  
Scoring Systems ◽  
Cell Junction ◽  
Interleukin 17 ◽  
Gamma Chain ◽  
Novel Approach ◽  
Interleukin 23

Aims and methodsAccurate protein measurements using formalin-fixed biopsies are needed to improve disease characterisation. This feasibility study used targeted and global mass spectrometry (MS) to interrogate a spectrum of disease severities using 19 ulcerative colitis (UC) biopsies.ResultsTargeted assays for CD8, CD19, CD132 (interleukin-2 receptor subunit gamma/common cytokine receptor gamma chain), FOXP3 (forkhead box P3) and IL17RA (interleukin 17 receptor A) were successful; however, assays for IL17A (interleukin 17A), IL23 (p19) (interleukin 23, alpha subunit p19) and IL23R (interleukin 23 receptor) did not permit target detection. Global proteome analysis (4200 total proteins) was performed to identify pathways associated with UC progression. Positive correlation was observed between histological scores indicating active colitis and neutrophil-related measurements (R2=0.42–0.72); inverse relationships were detected with cell junction targets (R2=0.49–0.71) and β-catenin (R2=0.51–0.55) attributed to crypt disruption. An exploratory accuracy assessment with Geboes Score and Robarts Histopathology Index cut-offs produced sensitivities/specificities of 72.7%/75.0% and 100.0%/81.8%, respectively.ConclusionsPathologist-guided MS assessments provide a complementary approach to histological scoring systems. Additional studies are indicated to verify the utility of this novel approach.

The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis

2014 ◽  
Vol 26 (4) ◽  
pp. 361-370 ◽  
Author(s):  
Nataliya Yeremenko ◽  
Jacqueline E. Paramarta ◽  
Dominique Baeten
Keyword(s):  
Interleukin 17 ◽  
Interleukin 23

Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype

2015 ◽  
Vol 36 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Salvatore Leonardi ◽  
Caterina Cuppari ◽  
Sara Manti ◽  
Martina Filippelli ◽  
Giuseppe Fabio Parisi ◽  
...  
Keyword(s):  
Atopic Eczema ◽  
Interleukin 10 ◽  
Clinical Severity ◽  
Interleukin 17 ◽  
Interleukin 23

Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product–induced interleukin-23/interleukin-17 immune response in rats

Nutrition ◽  
2012 ◽  
Vol 28 (10) ◽  
pp. 1063-1067 ◽  
Author(s):  
Chiu-Li Yeh ◽  
Ya-Mei Hu ◽  
Jun-Jen Liu ◽  
Wei-Jao Chen ◽  
Sung-Ling Yeh
Keyword(s):  
Immune Response ◽  
Interleukin 17 ◽  
Interleukin 23 ◽  
Advanced Glycosylation

An insight into anti-arthritic property of phytochemicals against Rheumatoid arthritis using molecular modelling and docking approach

2021 ◽  
Vol 16 (12) ◽  
pp. 185-195
Author(s):  
Bharathi Nathan ◽  
Sudheer M.M. Mohammed
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Targets ◽  
Joint Inflammation ◽  
Binding Energies ◽  
Multiple Drug ◽  
Matrix Metalloproteinase 3 ◽  
Drug Candidates ◽  
Docking Tool ◽  
Docking Approach ◽  
Interleukin 23

Arthritis literally refers “joint inflammation”, it is a condition where one or more joints are inflamed. More than 100 different types of Arthritis were identified, most common types are rheumatoid arthritis and osteoarthritis. The present study mainly focuses on the development of the novel phytochemical inhibitors against rheumatoid arthritis and osteoarthritis using an integrative cheminformatics drug discovery platform. In this study, we identified potential 405 phytochemical drug candidates, screened against eight selected targets of rheumatoid arthritis and osteoarthritis using molecular docking tool AutoDock. Three phytochemicals Withanolide, Diosgenin and bamyrin exhibited promising binding towards multiple drug targets selected for this study. When comparing with the binding between reference drugs, withanolide showed highest activity against Interleukin-23, Matrix metalloproteinase-3 and Interleukin 8 with binding energies -11.6, -9.4 and -8.3 kcal/mol respectively. Diosgenin also exhibited best activity against three targets that were Interleukin-23, JNK alpha and MMP-3 with -11.3, -10.4, -9.5 kcal/mol binding energies respectively. This study may be important contributing factor to develop new therapeutic drugs for rheumatoid arthritis and osteoarthritis.

Sign in / Sign up

Export Citation Format

Share Document