FRI0412 Urinalysis Findings and Renal Pathology in Japanese Patients with Lupus Nephritis: Table 1.

Background: Lupus nephritis (LN) often lead to end-stage renal disease in systemic lupus erythematosus patients. This study aimed to investigate the clinical application of renal gallium-67 scans for determining renal histological parameters in LN patients. Methods: Between 2006 and 2018, 237 biopsy-proven and 35 repeat biopsies LN patients who underwent renal gallium scans before or after biopsy were included for analysis. The classification and scoring of LN were assessed according to the International Society of Nephrology/Renal Pathology Society. A delayed 48-h gallium scan was performed and interpreted by semiquantitative methods using left kidney/spine (K/S) ratio. The renal histological results were compared with gallium uptake. Results: Out of 237 participants, 180 (76%) had proliferative LN. Baseline gallium left K/S ratio was significantly higher in class IV LN as compared to class III (median (interquartile range, IQR): 1.16 (1.0–1.3), 0.95 (0.9–1.1), respectively, p < 0.001). Furthermore, changes in gallium uptake between two biopsies were positively correlated with changes activity index (r = 0.357, p = 0.035), endocapillary hypercellularity (r = 0.385, p = 0.032), and neutrophils infiltration (r = 0.390, p = 0.030) in renal pathology. Conclusions: Renal gallium uptake is associated with active inflammation in LN. Changes in renal gallium uptake positively correlated with changes in activity index in renal pathology.

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The predictive value of crescents in the disease progression of lupus nephritis based on the 2018 International Society of Nephrology/Renal Pathology Society Revision System: a large cohort study from China

Renal Failure ◽

10.1080/0886022x.2020.1726385 ◽

2020 ◽

Vol 42 (1) ◽

pp. 166-172

Author(s):

Juan Tao ◽

Hui Wang ◽

Su-Xia Wang ◽

Feng Yu ◽

Ming-Hui Zhao

Keyword(s):

Cohort Study ◽

Lupus Nephritis ◽

Disease Progression ◽

International Society ◽

Predictive Value ◽

Large Cohort ◽

Renal Pathology ◽

System A ◽

Large Cohort Study

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Urine VCAM1 is a Good Indicator of Renal Pathology “Activity Index” in Lupus Nephritis

Clinical Immunology ◽

10.1016/j.clim.2010.03.244 ◽

2010 ◽

Vol 135 ◽

pp. S81

Author(s):

Sandeep Singh ◽

Tianfu Wu ◽

Kamala Vanarsa ◽

Tina Mahajan ◽

Ho Bing ◽

...

Keyword(s):

Lupus Nephritis ◽

Activity Index ◽

Renal Pathology

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A clinico-pathological study of lupus nephritis based on the International Society of Nephrology-Renal Pathology Society 2003 classification system

Journal of Laboratory Physicians ◽

10.4103/jlp.jlp_44_16 ◽

2017 ◽

Vol 9 (03) ◽

pp. 149-155

Author(s):

Suchitha Satish ◽

Pallavi Deka ◽

Manjunath Sanjeev Shetty

Keyword(s):

Lupus Nephritis ◽

Renal Biopsy ◽

International Society ◽

Lupus Erythematosus ◽

Classification System ◽

Renal Involvement ◽

Response To Therapy ◽

Renal Pathology ◽

Laboratory Findings ◽

Presenting Symptoms

Abstract INTRODUCTION: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). Renal involvement is a major determinant of the prognosis of SLE. The histological classification of LN is a key factor in determining the renal survival of patients with LN. Prompt recognition and treatment of renal disease are important, as early response to therapy is correlated with better outcome and renal biopsy plays an important role in achieving this. OBJECTIVES: The objective of this study was to correlate the clinical and laboratory findings with histopathological classes of LN as per the 2003 International Society of Nephrology-Renal Pathology Society (ISN/RPS) classification system. PATIENTS AND METHODS: Fifty-six patients with SLE, undergoing a renal biopsy for renal dysfunction were studied. The comparison of data from multiple groups was made by Pearson’s Chi-square test and between two groups by independent samples t-test. The values of P < 0.05 were considered statistically significant. RESULTS: Of the 56 cases studied, 51 (91.1%) were females. The most common presenting symptoms were edema, arthralgia, and hypertension. Class IV (55.4%) was the most common class. Thirty-nine (69.6%) cases showed full house immunostaining. Hypertension, hematuria, proteinuria, and tu bulo-interstitial disease showed a significant correlation (P < 0.05) with ISN/RPS classification, 2003. CONCLUSION: Assessment and management of patients with suspected LN are greatly facilitated through information obtained by renal biopsy. Since renal morphology may predict long-term prognosis, and no clinical or laboratory feature uniformly predicts prognosis, it is important to study the constellation of features in LN for better patient management.

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